10-(4-methoxyphenyl)-3-(4-methylphenyl)-8,9-dihydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-4(7H)-one

Base Information

• Chemical Name: 10-(4-methoxyphenyl)-3-(4-methylphenyl)-8,9-dihydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-4(7H)-one
• CAS No.: 345912-81-4
• Molecular Formula: C₂₅H₂₀N₄O₂S
• Molecular Weight: 440.525
• Mol file: 345912-81-4.mol

Synonyms:

Chemical Property of 10-(4-methoxyphenyl)-3-(4-methylphenyl)-8,9-dihydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-4(7H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 10-(4-methoxyphenyl)-3-(4-methylphenyl)-8,9-dihydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-4(7H)-one

There total 4 articles about 10-(4-methoxyphenyl)-3-(4-methylphenyl)-8,9-dihydro-3H-cyclopenta[5',6']pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-4(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-amino-4-(4-methoxy-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide (345912-42-7) → 4-(4-methoxy-phenyl)-7-p-tolyl-2,3-dihydro-1H,7H-9-thia-5,6,7,10-tetraaza-cyclopenta[b]fluoren-8-one (345912-81-4)

Guidance literature:

With sulfuric acid; acetic acid; sodium nitrite; at 0 ℃;

DOI:10.1080/10426500008076538

Reference yield:

N-(p-tolyl)-2-chloroacetamide (16634-82-5) → 4-(4-methoxy-phenyl)-7-p-tolyl-2,3-dihydro-1H,7H-9-thia-5,6,7,10-tetraaza-cyclopenta[b]fluoren-8-one (345912-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / AcONa*3H₂O / ethanol / 2 h / Heating

2: 90 percent / EtONa / ethanol / 0.08 h / Heating

3: 77 percent / NaNO₂; AcOH; H₂SO₄ / 0 °C

With sulfuric acid; sodium ethanolate; sodium acetate; acetic acid; sodium nitrite; In ethanol; 2: Thorpe-Ziegler cyclization;

DOI:10.1080/10426500008076538

Reference yield:

4-(4-methoxyphenyl)-2-sulfanylidene-1H,2H,5H,6H,7H-cyclopenta[b]pyridine-3-carbonitrile (120517-49-9) → 4-(4-methoxy-phenyl)-7-p-tolyl-2,3-dihydro-1H,7H-9-thia-5,6,7,10-tetraaza-cyclopenta[b]fluoren-8-one (345912-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / AcONa*3H₂O / ethanol / 2 h / Heating

2: 90 percent / EtONa / ethanol / 0.08 h / Heating

3: 77 percent / NaNO₂; AcOH; H₂SO₄ / 0 °C

With sulfuric acid; sodium ethanolate; sodium acetate; acetic acid; sodium nitrite; In ethanol; 2: Thorpe-Ziegler cyclization;

DOI:10.1080/10426500008076538

upstream raw materials:

3-amino-4-(4-methoxy-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide

N-(p-tolyl)-2-chloroacetamide

4-(4-methoxyphenyl)-2-sulfanylidene-1H,2H,5H,6H,7H-cyclopenta[b]pyridine-3-carbonitrile

2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-N-p-tolyl-acetamide

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