Technology Process of 2-(3,5-dimethyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetic acid
There total 8 articles about 2-(3,5-dimethyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: palladium diacetate; triphenylphosphine / 85 °C
3.1: silica gel / 85 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0 °C
4.2: 20 °C
5.1: sodium hydroxide / methanol / 20 °C
With
potassium tert-butylate; palladium diacetate; silica gel; potassium carbonate; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
2.1: intramolecular Heck cyclization;
DOI:10.1016/j.bmcl.2011.01.008
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium diacetate; triphenylphosphine / 85 °C
2.1: silica gel / 85 °C
3.1: potassium tert-butylate / tetrahydrofuran / 0 °C
3.2: 20 °C
4.1: sodium hydroxide / methanol / 20 °C
With
potassium tert-butylate; palladium diacetate; silica gel; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol;
1.1: intramolecular Heck cyclization;
DOI:10.1016/j.bmcl.2011.01.008
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diphenylphosphoranyl azide; triethylamine / 65 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
3.1: palladium diacetate; triphenylphosphine / 85 °C
4.1: silica gel / 85 °C
5.1: potassium tert-butylate / tetrahydrofuran / 0 °C
5.2: 20 °C
6.1: sodium hydroxide / methanol / 20 °C
With
diphenylphosphoranyl azide; potassium tert-butylate; palladium diacetate; silica gel; potassium carbonate; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
1.1: Curtius rearrangement / 3.1: intramolecular Heck cyclization;
DOI:10.1016/j.bmcl.2011.01.008
