hexacarbonyl[1-{4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt

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Chemical Name:hexacarbonyl[1-{4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt
CAS No.:1412443-44-7
Molecular Formula:C₂₆H₂₅Co₂F₂NO₁₀
Molecular Weight:667.468
Hs Code.:

Synonyms:

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Chemical Property of hexacarbonyl[1-{4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt

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Technology Process of hexacarbonyl[1-{4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt

There total 4 articles about hexacarbonyl[1-{4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15226-74-1,61091-28-9,61117-58-6
dicobalt octacarbonyl

: 1412443-36-7
1-{4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy] phenyl}-3-N-Boc-methylaminoprop-2-yn-ol

: 1412443-44-7
hexacarbonyl[1-{4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt

Guidance literature:: In dichloromethane; for 0.166667h; Inert atmosphere;
DOI:10.1016/j.tet.2012.08.087

Reference yield:

: 1412443-28-7
4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]benzaldehyde

: 1412443-44-7
hexacarbonyl[1-{4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: dichloromethane / 0.17 h / Inert atmosphere

With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane;
DOI:10.1016/j.tet.2012.08.087

Reference yield:

: 199287-52-0
4,5-difluoro-2-hydroxybenzaldehyde

: 1412443-44-7
hexacarbonyl[1-{4,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: dichloromethane / 0.17 h / Inert atmosphere

With potassium carbonate; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.08.087