5-bromo-2-(methylthio)nicotinic acid

Base Information

• Chemical Name: 5-bromo-2-(methylthio)nicotinic acid
• CAS No.: 1220422-10-5
• Molecular Formula: C₇H₆BrNO₂S
• Molecular Weight: 248.1
• Mol file: 1220422-10-5.mol

Synonyms:

Chemical Property of 5-bromo-2-(methylthio)nicotinic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-(methylthio)nicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-2-(methylthio)nicotinic acid

There total 2 articles about 5-bromo-2-(methylthio)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-bromo-2-fluoro-pyridine-3-carboxylic acid (29241-66-5) + sodium thiomethoxide (5188-07-8) → 5-bromo-2-(methylthio)nicotinic acid (1220422-10-5)

Guidance literature:

5-bromo-2-fluoro-pyridine-3-carboxylic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 0.116667h;

sodium thiomethoxide; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere; Sealed tube;

Reference yield: 92.0%

sodium thiomethanolate + 5-bromo-2-fluoro-pyridine-3-carboxylic acid (29241-66-5) → 5-bromo-2-(methylthio)nicotinic acid (1220422-10-5)

Guidance literature:

5-bromo-2-fluoro-pyridine-3-carboxylic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 0.116667h; Inert atmosphere;

sodium thiomethanolate; Sealed tube; Inert atmosphere;

Reference yield:

5-bromo-2-(methylthio)nicotinic acid (1220422-10-5) → 3-fluoro-5-((1-(methylsulfonyl)-5,6-dihydrospiro[cyclopenta[c]pyridine-7,2'-[1,3]dioxolan]-4-yl)oxy)benzonitrile

Guidance literature:

Multi-step reaction with 8 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -50 °C

1.2: 0.25 h

2.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 25 °C

2.2: 2 h

3.1: cobalt(II) chloride hexahydrate; sodium tetrahydroborate; methanol / 0 °C / Inert atmosphere; Sealed tube

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C

4.2: 0.67 h / 150 °C / Microwave irradiation; Sealed tube

5.1: Oxone / water; methanol / 24 h / 0 °C

6.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 - 20 °C

6.2: 0.17 h

7.1: t-BuBrettPhos; potassium hydroxide; [(2-di-tert-butylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl)-2-(2’-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate / water; 1,4-dioxane / 1.5 h / 80 °C / Inert atmosphere; Sealed tube

8.1: potassium carbonate / acetonitrile / 0.17 h / 25 °C

8.2: 3 h / 50 °C

With 2,2,6,6-tetramethyl-piperidine; methanol; Oxone; sodium tetrahydroborate; n-butyllithium; cobalt(II) chloride hexahydrate; trimethylsilyl trifluoromethanesulfonate; t-BuBrettPhos; [(2-di-tert-butylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl)-2-(2’-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; acetonitrile;

upstream raw materials:

5-bromo-2-fluoro-pyridine-3-carboxylic acid

sodium thiomethoxide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1220422-10-5 5-bromo-2-(methylthio)nicotinic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send