(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-N-[(2R)-1-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]oxolane-2-carboxamide

Base Information

Chemical Name:(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-N-[(2R)-1-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]oxolane-2-carboxamide
CAS No.:1414799-89-5
Molecular Formula:C₂₇H₃₄N₆O₉
Molecular Weight:586.602
Hs Code.:

(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-N-[(2R)-1-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]oxolane-2-carboxamide

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Chemical Property of (2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-N-[(2R)-1-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]oxolane-2-carboxamide

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Technology Process of (2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-N-[(2R)-1-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]oxolane-2-carboxamide

There total 5 articles about (2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-N-[(2R)-1-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]oxolane-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71774-76-0
2’,3’-O-isopropylideneuridine-5’-carboxylic acid

: 1414799-89-5
(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-N-[(2R)-1-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]oxolane-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

2: sodium hydroxide; water / 1,4-dioxane / 1 h

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

4: formic acid / 70 °C

With formic acid; water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In 1,4-dioxane; acetonitrile;
DOI:10.1021/co4001452

Reference yield:

: 1590439-69-2
C₂₂H₂₅N₃O₈

: 1414799-89-5
(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-N-[(2R)-1-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]oxolane-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / 1,4-dioxane / 1 h

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

3: formic acid / 70 °C

With formic acid; water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In 1,4-dioxane; acetonitrile;
DOI:10.1021/co4001452