Technology Process of (1'R,4'S)-9-(4-benzyloxymethylcyclopent-2-enyl)-9H-purine-2,6-diamine
There total 6 articles about (1'R,4'S)-9-(4-benzyloxymethylcyclopent-2-enyl)-9H-purine-2,6-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
at 95 ℃;
for 3h;
DOI:10.1039/P19910002479
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) NaH, 2) 15-crown-5 / 1) DMF, 85 deg C, 20 min, 2) DMF, 100 deg C, 3 h
2: 92 percent / 4-dimethylaminopyridine / CH2Cl2 / 1) -20 deg C, 1 h, 2) -15 deg C, 0.75 h
3: 38 percent / pyridine, azoisobutyronitrile, tributyltin hydride / 3 h / 95 °C
With
pyridine; dmap; 15-crown-5; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride;
In
dichloromethane;
DOI:10.1039/P19910002479
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 81 percent / 4-dimethylaminopyridine, Et3N / CH2Cl2 / 0.75 h / 0 °C
2: Bu4NF / tetrahydrofuran / 72 h / Ambient temperature
3: 1) NaH, 2) 15-crown-5 / 1) DMF, 85 deg C, 20 min, 2) DMF, 100 deg C, 3 h
4: 92 percent / 4-dimethylaminopyridine / CH2Cl2 / 1) -20 deg C, 1 h, 2) -15 deg C, 0.75 h
5: 38 percent / pyridine, azoisobutyronitrile, tributyltin hydride / 3 h / 95 °C
With
pyridine; dmap; 15-crown-5; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; sodium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/P19910002479
