(R)-((3R,4R,E)-6-iodo-4-methylhex-5-en-3-yl) 2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoate

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Chemical Name:(R)-((3R,4R,E)-6-iodo-4-methylhex-5-en-3-yl) 2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoate
CAS No.:865107-63-7
Molecular Formula:C₃₁H₄₉IO₆
Molecular Weight:644.631
Hs Code.:

(R)-((3R,4R,E)-6-iodo-4-methylhex-5-en-3-yl) 2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoate

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Chemical Property of (R)-((3R,4R,E)-6-iodo-4-methylhex-5-en-3-yl) 2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoate

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Technology Process of (R)-((3R,4R,E)-6-iodo-4-methylhex-5-en-3-yl) 2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoate

There total 10 articles about (R)-((3R,4R,E)-6-iodo-4-methylhex-5-en-3-yl) 2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₉Cl₃O₇

: 216493-79-7
(E)-(3R,4R)-6-iodo-4-methyl-5-hexen-3-ol

: 865107-63-7
(R)-((3R,4R,E)-6-iodo-4-methylhex-5-en-3-yl) 2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoate

Guidance literature:: With dmap; In benzene; at 20 ℃; for 24h;
DOI:10.1021/jo050924a

Reference yield:

: 865107-57-9
(2S,4R)-5-(4-methoxybenzyloxy)-2,4-dimethylpentyl acetate

: 865107-63-7
(R)-((3R,4R,E)-6-iodo-4-methylhex-5-en-3-yl) 2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 84 percent / LiAlH₄ / diethyl ether / 0 - 20 °C

2.1: 83 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 12 h / 20 °C

3.1: TiCl₄; i-Pr₂NEt / CH₂Cl₂; toluene / 1 h / -5 °C

3.2: 74 percent / CH₂Cl₂; toluene / 12.5 h / -78 - -50 °C

4.1: Zn(BH₄)2 / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

5.1: 3.80 g / CSA / 6 h / 20 °C

6.1: 90 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 7 h / 0 - 20 °C

7.1: Et₃N / tetrahydrofuran / 2 h / 20 °C

8.1: 0.29 g / DMAP / benzene / 24 h / 20 °C

With pyridine; dmap; lithium hydroxide; lithium aluminium tetrahydride; zinc(II) tetrahydroborate; camphor-10-sulfonic acid; dihydrogen peroxide; titanium tetrachloride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; benzene; 2.1: Dess-Martin oxidation;
DOI:10.1021/jo050924a

Reference yield:

: 865107-62-6
(R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoic acid

: 865107-63-7
(R)-((3R,4R,E)-6-iodo-4-methylhex-5-en-3-yl) 2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 2 h / 20 °C

2: 0.29 g / DMAP / benzene / 24 h / 20 °C

With dmap; triethylamine; In tetrahydrofuran; benzene;
DOI:10.1021/jo050924a