(S)-2-[(S)-2-(2-{2-Adamantan-1-yl-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid

Base Information

Chemical Name:(S)-2-[(S)-2-(2-{2-Adamantan-1-yl-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid
CAS No.:895166-94-6
Molecular Formula:C₃₇H₄₉N₅O₇S
Molecular Weight:707.891
Hs Code.:

(S)-2-[(S)-2-(2-{2-Adamantan-1-yl-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid

Synonyms:

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Chemical Property of (S)-2-[(S)-2-(2-{2-Adamantan-1-yl-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid

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Technology Process of (S)-2-[(S)-2-(2-{2-Adamantan-1-yl-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid

There total 6 articles about (S)-2-[(S)-2-(2-{2-Adamantan-1-yl-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 895167-17-6
2-[2-(2-{2-adamantan-1-yl-2-[2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid

: 895166-94-6
(S)-2-[(S)-2-(2-{2-Adamantan-1-yl-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid

Guidance literature:: With methoxybenzene; trifluoroacetic acid; at 20 ℃; for 0.5h;
DOI:10.1021/jm051026+

Reference yield:

: 895167-07-4
adamantan-1-yl-[2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-acetic acid

: 895166-94-6
(S)-2-[(S)-2-(2-{2-Adamantan-1-yl-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 57 percent / BOP; NMM; HOBt / dimethylformamide / 20 °C

2.1: NMM; isobutyl chloroformate / dimethylformamide / 0.03 h / -10 °C

2.2: dimethylformamide / -10 - 20 °C

3.1: aq. TFA; anisole / 0.5 h / 20 °C

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; methoxybenzene; trifluoroacetic acid; isobutyl chloroformate; In N,N-dimethyl-formamide;
DOI:10.1021/jm051026+

Reference yield:

: 895167-13-2
{2-adamantan-1-yl-2-[2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-acetylamino}-acetic acid

: 895166-94-6
(S)-2-[(S)-2-(2-{2-Adamantan-1-yl-2-[(S)-2-amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NMM; isobutyl chloroformate / dimethylformamide / 0.03 h / -10 °C

1.2: dimethylformamide / -10 - 20 °C

2.1: aq. TFA; anisole / 0.5 h / 20 °C

With 4-methyl-morpholine; methoxybenzene; trifluoroacetic acid; isobutyl chloroformate; In N,N-dimethyl-formamide;
DOI:10.1021/jm051026+