5-(3-(2-(7-CHLOROQUINOLIN-2-YL)ETHENYL)PHENYL)-8-CARBAMYL-4,6-DITHIAOCTANOIC ACID

Base Information

Chemical Name:5-(3-(2-(7-CHLOROQUINOLIN-2-YL)ETHENYL)PHENYL)-8-CARBAMYL-4,6-DITHIAOCTANOIC ACID
CAS No.:143816-56-2
Molecular Formula:C₂₄H₂₃ClN₂O₃S₂
Molecular Weight:487.043
Hs Code.:

Synonyms:

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Chemical Property of 5-(3-(2-(7-CHLOROQUINOLIN-2-YL)ETHENYL)PHENYL)-8-CARBAMYL-4,6-DITHIAOCTANOIC ACID

Chemical Property:

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Technology Process of 5-(3-(2-(7-CHLOROQUINOLIN-2-YL)ETHENYL)PHENYL)-8-CARBAMYL-4,6-DITHIAOCTANOIC ACID

There total 8 articles about 5-(3-(2-(7-CHLOROQUINOLIN-2-YL)ETHENYL)PHENYL)-8-CARBAMYL-4,6-DITHIAOCTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1028266-50-3
3-((2-Carbamoyl-ethylsulfanyl)-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-methylsulfanyl)-propionic acid methyl ester

: 143816-56-2
5-(3-(2-(7-CHLOROQUINOLIN-2-YL)ETHENYL)PHENYL)-8-CARBAMYL-4,6-DITHIAOCTANOIC ACID

Guidance literature:: With lithium hydroxide; In 1,2-dimethoxyethane; for 1h;
DOI:10.1021/jm00099a011

Reference yield:

: 4965-33-7
2-methyl-7-chloroquinoline

: 143816-56-2
5-(3-(2-(7-CHLOROQUINOLIN-2-YL)ETHENYL)PHENYL)-8-CARBAMYL-4,6-DITHIAOCTANOIC ACID

Guidance literature:: Multi-step reaction with 5 steps

1: 46 percent / NBS, benzoyl peroxide / CCl₄ / 48 h / Heating; Irradiation

2: 72 percent / acetonitrile / 60 °C

3: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT

4: trimethylaluminum, NH₃ / hexane; toluene / 8 h / Ambient temperature

5: aq. 1N LiOH / 1,2-dimethoxy-ethane / 1 h

With lithium hydroxide; N-Bromosuccinimide; n-butyllithium; Perbenzoic acid; ammonia; trimethylaluminum; In tetrachloromethane; 1,2-dimethoxyethane; hexane; toluene; acetonitrile;
DOI:10.1021/jm00099a011

Reference yield:

: 626-19-7
Isophthalaldehyde

: 143816-56-2
5-(3-(2-(7-CHLOROQUINOLIN-2-YL)ETHENYL)PHENYL)-8-CARBAMYL-4,6-DITHIAOCTANOIC ACID

Guidance literature:: Multi-step reaction with 4 steps

1: 37 percent / trimethylsilyl chloride / CHCl₃ / 2 h / Ambient temperature

2: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT

3: trimethylaluminum, NH₃ / hexane; toluene / 8 h / Ambient temperature

4: aq. 1N LiOH / 1,2-dimethoxy-ethane / 1 h

With lithium hydroxide; n-butyllithium; chloro-trimethyl-silane; ammonia; trimethylaluminum; In 1,2-dimethoxyethane; hexane; chloroform; toluene;
DOI:10.1021/jm00099a011