Benzenepentanol, 4-methylbenzenesulfonate

Base Information

• Chemical Name: Benzenepentanol, 4-methylbenzenesulfonate
• CAS No.: 109398-68-7
• Molecular Formula: C18H22O3S
• Molecular Weight: 318.437
• Mol file: 109398-68-7.mol

Synonyms:

Chemical Property of Benzenepentanol, 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepentanol, 4-methylbenzenesulfonate

There total 7 articles about Benzenepentanol, 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-phenylpentan-1-ol (10521-91-2) + p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulphonic acid 5-phenyl-pentyl ester (109398-68-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

5-Phenylpentanoic acid (2270-20-4) → toluene-4-sulphonic acid 5-phenyl-pentyl ester (109398-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether

2: Py / 0.5 h / 0 °C

With pyridine; lithium aluminium tetrahydride; In diethyl ether;

Reference yield:

1-Bromo-3-phenylpropane (637-59-2) → toluene-4-sulphonic acid 5-phenyl-pentyl ester (109398-68-7)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) NaH, DMF, (ii) /BRN= 2205527/

2: aq. KOH / ethane-1,2-diol / 48 h / Heating

3: (decarboxylation)

4: LiAlH₄ / diethyl ether

5: Py / 0.5 h / 0 °C

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; In diethyl ether; ethylene glycol;

upstream raw materials:

5-phenylpentan-1-ol

p-toluenesulfonyl chloride

5-Phenylpentanoic acid

1-Bromo-3-phenylpropane

Downstream raw materials:

2-Cyan-7-phenyl-heptansaeure-aethylester

N-methyl-N-(5-phenylpentyl)amine

α-benzyl-N-tert-butoxycarbonylpyrrolidine

tert-butyl 2-phenylipiperidine-1-carboxylate

Refernces

• 1、 Shing, Ka-Pan,Liu, Yungen,Cao, Bei,Chang, Xiao-Yong,You, Tingjie,Che, Chi-Ming. "N-Heterocyclic Carbene Iron(III) Porphyrin-Catalyzed Intramolecular C(sp3)–H Amination of Alkyl Azides". supporting information. p. 11947 - 11951. Retrieved 2018/09/11.
• 2、 Lai, Gaifa,Tan, Ping-Zhong,Ghoshal, Pallab. "A one-pot method for the efficient conversion of aryl- and acyl-substituted methyl alcohols into chlorides". . p. 1727 - 1732. Retrieved 2007/10/03.