Technology Process of LASSBio-1762
There total 4 articles about LASSBio-1762 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 1,4-dioxane / 12 h / 0 - 20 °C / Inert atmosphere
2.1: potassium hydroxide / 0.08 h / 20 °C
2.2: 0.33 h / 20 °C
3.1: lithium carbonate / acetonitrile / 20 h / 80 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / methanol; ethanol / 3 h / 20 °C / 2068.65 Torr
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; lithium carbonate; triethylamine; potassium hydroxide;
In
1,4-dioxane; methanol; ethanol; acetonitrile;
1.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2013.05.027
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydroxide / 0.08 h / 20 °C
1.2: 0.33 h / 20 °C
2.1: lithium carbonate / acetonitrile / 20 h / 80 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / methanol; ethanol / 3 h / 20 °C / 2068.65 Torr
With
palladium 10% on activated carbon; hydrogen; lithium carbonate; potassium hydroxide;
In
methanol; ethanol; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.027
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium carbonate / acetonitrile / 20 h / 80 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / methanol; ethanol / 3 h / 20 °C / 2068.65 Torr
With
palladium 10% on activated carbon; hydrogen; lithium carbonate;
In
methanol; ethanol; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.027
