Technology Process of 10-methyl-4-phenyl-10-(3-phenylpropyl)-2,4,6-triazatricyclo<5.2.1.02,6>decane-3,5-dione
There total 7 articles about 10-methyl-4-phenyl-10-(3-phenylpropyl)-2,4,6-triazatricyclo<5.2.1.02,6>decane-3,5-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 20h;
under 2844.3 Torr;
DOI:10.1021/ja00066a016
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) 1,10-phenathroline, diisopropylamine, n-BuLi, 2.) benzeneselenyl bromide, 3.) 30percent aq. H2O2
2: 58 percent / CeCl3*2H2O, NaBH4 / methanol / 0.08 h / 0 °C
3: 84 percent / N,N'-dimethylpropyleneurea (DMPU), methyltriphenoxyphosphonium iodide / 8.5 h / 70 °C
4: 98 percent / CH2Cl2 / 0.25 h
5: 90 percent / H2 / 5percent Pd/C / methanol / 20 h / 2844.3 Torr
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; n-butyllithium; 1,10-Phenanthroline; cerium(III) chloride; Phenylselenyl bromide; methyltriphenoxyphosphonium iodide; hydrogen; dihydrogen peroxide; diisopropylamine;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1021/ja00066a016
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) Mg, 2.) (Bu3P)CuI / 1.) Et2O, 20 min, 2.) Et2O, 0 deg C, 30 min
2: 1.) 1,10-phenathroline, diisopropylamine, n-BuLi, 2.) benzeneselenyl bromide, 3.) 30percent aq. H2O2
3: 58 percent / CeCl3*2H2O, NaBH4 / methanol / 0.08 h / 0 °C
4: 84 percent / N,N'-dimethylpropyleneurea (DMPU), methyltriphenoxyphosphonium iodide / 8.5 h / 70 °C
5: 98 percent / CH2Cl2 / 0.25 h
6: 90 percent / H2 / 5percent Pd/C / methanol / 20 h / 2844.3 Torr
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; n-butyllithium; 1,10-Phenanthroline; cerium(III) chloride; CuI*P(n-Bu)3; Phenylselenyl bromide; methyltriphenoxyphosphonium iodide; hydrogen; dihydrogen peroxide; magnesium; diisopropylamine;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1021/ja00066a016
