(+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-6-methoxy-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}

Base Information

• Chemical Name: (+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-6-methoxy-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}
• CAS No.: 945674-93-1
• Molecular Formula: C₃₅H₃₆ClN₃O₄
• Molecular Weight: 598.142
• Mol file: 945674-93-1.mol

Synonyms:

Chemical Property of (+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-6-methoxy-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-6-methoxy-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}

There total 2 articles about (+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-6-methoxy-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-[2-(dimethylamino)ethoxy]-6-methoxy-1H-indole-2-carboxylic acid hydrochloride + 5-benzyloxy-1-(1-chloro-ethyl)-2,3-dihydro-1H-benzo[e]indole → (+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-6-methoxy-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole} (945674-93-1)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1002/chem.200700113

Reference yield:

(+)-(1S,10R)-5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(10-chloroethyl)-1,2-dihydro-3H-benz[e]indole (916667-93-1) → (+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-6-methoxy-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole} (945674-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / ethyl acetate / 3.5 h / 20 °C

2: 134 mg / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1002/chem.200700113

upstream raw materials:

(+)-(1S,10R)-5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(10-chloroethyl)-1,2-dihydro-3H-benz[e]indole