Technology Process of (5Z,8Z,13E)-(11R,12R,15S)-11,12,15-Trihydroxy-icosa-5,8,13-trienoic acid
There total 7 articles about (5Z,8Z,13E)-(11R,12R,15S)-11,12,15-Trihydroxy-icosa-5,8,13-trienoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 98 percent / H2 / Ni (P-2) / ethanol / 12 h / 23 °C / 760 Torr
2: 95 percent / PBr3 / diethyl ether / 1 h / 0 °C
3: CuCN / tetrahydrofuran / 4 h / 50 °C
4: aq. AcOH / 12 h / 23 °C
5: aq. NaIO4 / tetrahydrofuran / 1 h / -10 °C
6: NiCl2; CrCl2 / dimethylformamide / 12 h / 23 °C
7: H2O2; NaOH / methanol / 10 h / 23 °C
With
chromium dichloride; sodium hydroxide; sodium periodate; hydrogen; dihydrogen peroxide; phosphorus tribromide; acetic acid; nickel dichloride;
nickel;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide;
6: Nozaki-Kishi addition;
DOI:10.1016/j.bmcl.2004.07.019
- Guidance literature:
-
Multi-step reaction with 5 steps
1: CuCN / tetrahydrofuran / 4 h / 50 °C
2: aq. AcOH / 12 h / 23 °C
3: aq. NaIO4 / tetrahydrofuran / 1 h / -10 °C
4: NiCl2; CrCl2 / dimethylformamide / 12 h / 23 °C
5: H2O2; NaOH / methanol / 10 h / 23 °C
With
chromium dichloride; sodium hydroxide; sodium periodate; dihydrogen peroxide; acetic acid; nickel dichloride;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
4: Nozaki-Kishi addition;
DOI:10.1016/j.bmcl.2004.07.019
