(2S,1RS)-2-amino-3-methyl-1--1-butanol

Base Information

Chemical Name:(2S,1RS)-2-amino-3-methyl-1--1-butanol
CAS No.:137301-74-7
Molecular Formula:C₁₂H₁₆F₃NO
Molecular Weight:247.26
Hs Code.:

(2S,1RS)-2-amino-3-methyl-1-<p-(trifluoromethyl)phenyl>-1-butanol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,1RS)-2-amino-3-methyl-1--1-butanol

Chemical Property:

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Technology Process of (2S,1RS)-2-amino-3-methyl-1--1-butanol

There total 5 articles about (2S,1RS)-2-amino-3-methyl-1--1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

: 137301-72-5,137301-73-6
<(2S,1RS)>-2-<(benzyloxycarbonyl)amino>-3-methyl-1--1-butanol

: 137301-74-7,137332-27-5
(2S,1RS)-2-amino-3-methyl-1--1-butanol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2327.2 Torr;
DOI:10.1021/jm00082a005

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 137301-74-7,137332-27-5
(2S,1RS)-2-amino-3-methyl-1--1-butanol

Guidance literature:: Multi-step reaction with 4 steps

1: CDI / tetrahydrofuran

2: 1.) Mg / 1.) THF, reflux, 3.5 h, 2.) THF, RT, 15 min

3: 79 percent / NaBH₄ / methanol

4: 83.5 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

With sodium tetrahydroborate; hydrogen; magnesium; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00082a005

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 137301-74-7,137332-27-5
(2S,1RS)-2-amino-3-methyl-1--1-butanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Mg / 1.) THF, reflux, 3.5 h, 2.) THF, RT, 15 min

2: 79 percent / NaBH₄ / methanol

3: 83.5 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

With sodium tetrahydroborate; hydrogen; magnesium; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm00082a005