[(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile

Base Information

Chemical Name:[(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile
CAS No.:87231-35-4
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:

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Chemical Property of [(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile

Chemical Property:

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Technology Process of [(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile

There total 13 articles about [(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96724-73-1
N-benzyl-1-(2,4-dimethoxyphenyl)methanamine

: 87231-35-4,96725-00-7
[(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 11 steps

1: NaBH₄ / dioxane / 72 h / Ambient temperature

2: 81 percent / Ambient temperature

3: 97 percent / H₂ / 8percent Pd/C / ethanol / Ambient temperature

4: 60 percent / acetic acid / Heating

5: 54 percent / NaOEt, I₂ / ethanol; diethyl ether

6: BF₃-diethyl etherate / dioxane / 24 h / Ambient temperature

7: NaCl / H₂O; dimethylsulfoxide / 15 h / 180 °C

8: 69 percent / NaBH₄ / methanol / Ambient temperature

9: 62 percent / pyridine / 0.25 h / ice-cooling

10: 84 percent / NaI / acetone / 4 h / Heating

11: dimethylformamide / 24 h / Ambient temperature

With sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; iodine; sodium ethanolate; sodium iodide; sodium chloride; palladium on activated charcoal; In 1,4-dioxane; pyridine; methanol; diethyl ether; ethanol; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)96442-7

Reference yield:

: 83304-61-4
diethyl(N-benzyl)-N-(2,4-dimethoxy-benzyl)-amino-malonate

: 87231-35-4,96725-00-7
[(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / H₂ / 8percent Pd/C / ethanol / Ambient temperature

2: 60 percent / acetic acid / Heating

3: 54 percent / NaOEt, I₂ / ethanol; diethyl ether

4: BF₃-diethyl etherate / dioxane / 24 h / Ambient temperature

5: NaCl / H₂O; dimethylsulfoxide / 15 h / 180 °C

6: 69 percent / NaBH₄ / methanol / Ambient temperature

7: 62 percent / pyridine / 0.25 h / ice-cooling

8: 84 percent / NaI / acetone / 4 h / Heating

9: dimethylformamide / 24 h / Ambient temperature

With sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; iodine; sodium ethanolate; sodium iodide; sodium chloride; palladium on activated charcoal; In 1,4-dioxane; pyridine; methanol; diethyl ether; ethanol; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)96442-7

Reference yield:

: 83304-60-3
benzyl (2,4-dimethoxybenzyl)-amine

: 87231-35-4,96725-00-7
[(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 10 steps

1: 81 percent / Ambient temperature

2: 97 percent / H₂ / 8percent Pd/C / ethanol / Ambient temperature

3: 60 percent / acetic acid / Heating

4: 54 percent / NaOEt, I₂ / ethanol; diethyl ether

5: BF₃-diethyl etherate / dioxane / 24 h / Ambient temperature

6: NaCl / H₂O; dimethylsulfoxide / 15 h / 180 °C

7: 69 percent / NaBH₄ / methanol / Ambient temperature

8: 62 percent / pyridine / 0.25 h / ice-cooling

9: 84 percent / NaI / acetone / 4 h / Heating

10: dimethylformamide / 24 h / Ambient temperature

With sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; iodine; sodium ethanolate; sodium iodide; sodium chloride; palladium on activated charcoal; In 1,4-dioxane; pyridine; methanol; diethyl ether; ethanol; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)96442-7