3-(3-hydroxyphenyl)-4-methyl-2-(4-(2-(4-methylpiperidin-1-yl)ethoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

Base Information

Chemical Name:3-(3-hydroxyphenyl)-4-methyl-2-(4-(2-(4-methylpiperidin-1-yl)ethoxy)phenyl)-2H-chromen-6-ol trifluoroacetate
CAS No.:1352307-24-4
Molecular Formula:C₂HF₃O₂*C₃₀H₃₃NO₄
Molecular Weight:585.62
Hs Code.:

Synonyms:

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Chemical Property of 3-(3-hydroxyphenyl)-4-methyl-2-(4-(2-(4-methylpiperidin-1-yl)ethoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

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Technology Process of 3-(3-hydroxyphenyl)-4-methyl-2-(4-(2-(4-methylpiperidin-1-yl)ethoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

There total 12 articles about 3-(3-hydroxyphenyl)-4-methyl-2-(4-(2-(4-methylpiperidin-1-yl)ethoxy)phenyl)-2H-chromen-6-ol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₄₉NO₆

: 76-05-1
trifluoroacetic acid

: 1352307-24-4
3-(3-hydroxyphenyl)-4-methyl-2-(4-(2-(4-methylpiperidin-1-yl)ethoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

Guidance literature:: C₄₀H₄₉NO₆; With acetic acid; In water; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00921

Reference yield:

: 626-58-4
4-methylpiperidin

: 1352307-24-4
3-(3-hydroxyphenyl)-4-methyl-2-(4-(2-(4-methylpiperidin-1-yl)ethoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / chloroform / 48 h / 20 °C

2: caesium carbonate; copper(l) iodide / 48 h / 125 °C / Inert atmosphere

3: acetic acid / water / 20 °C

With copper(l) iodide; caesium carbonate; acetic acid; triethylamine; In chloroform; water; 2: |Ullmann Condensation;
DOI:10.1021/acs.jmedchem.8b00921

Reference yield:

: 2785-98-0
2,5-dimethoxybenzoic acid

: 1352307-24-4
3-(3-hydroxyphenyl)-4-methyl-2-(4-(2-(4-methylpiperidin-1-yl)ethoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: magnesium; iodine / tetrahydrofuran / 20 - 60 °C

2.2: 1 h / 0 °C

3.1: boron tribromide / dichloromethane / 0.5 h / -78 - 0 °C

4.1: pyridinium p-toluenesulfonate / dichloromethane / 1 h / 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; piperidine / iso-butanol / 1.5 h / Dean-Stark; Reflux

6.1: tetrahydrofuran / 0 - 20 °C

7.1: acetic acid / water / 90 °C

8.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C

9.1: caesium carbonate; copper(l) iodide / 48 h / 125 °C / Inert atmosphere

10.1: acetic acid / water / 20 °C

With piperidine; copper(l) iodide; oxalyl dichloride; iodine; pyridinium p-toluenesulfonate; boron tribromide; caesium carbonate; magnesium; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; iso-butanol; 9.1: |Ullmann Condensation;
DOI:10.1021/acs.jmedchem.8b00921