3-Quinolinecarboxylic acid, 8-broMo-6,7-difluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-, ethyl ester, trans- (9CI)

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 8-broMo-6,7-difluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-, ethyl ester, trans- (9CI)
• CAS No.: 166973-67-7
• Molecular Formula: C₁₅H₁₁BrF₃NO₃
• Molecular Weight: 390.156
• Mol file: 166973-67-7.mol

Synonyms:

Chemical Property of 3-Quinolinecarboxylic acid, 8-broMo-6,7-difluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-, ethyl ester, trans- (9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 8-broMo-6,7-difluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-, ethyl ester, trans- (9CI)

There total 2 articles about 3-Quinolinecarboxylic acid, 8-broMo-6,7-difluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-, ethyl ester, trans- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(3-bromo-2,4,5-trifluorobenzoyl)-3-{[(1R,2S)-2-fluorocyclopropyl]amino}acrylate ethyl ester → 8-bromo-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (166973-67-7)

Guidance literature:

With sodium carbonate; In acetone; Reflux;

Reference yield:

ethyl 2-(3-bromo-2,4,5-trifluoro-benzoyl)-3-(trans-2-fluoro-cyclopropylamino)-acrylate → ethyl 8-bromo-6,7-difluoro-1-(trans-2-fluorocyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate (166973-67-7)

Guidance literature:

With sodium fluoride; In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;