9-[2-(HYDROXYPROPYL-D6)] ADENINE

Base Information

• Chemical Name: 9-[2-(HYDROXYPROPYL-D6)] ADENINE
• CAS No.: 1020719-54-3
• Molecular Formula: C₈H₁₁N₅O
• Molecular Weight: 199.161
• Mol file: 1020719-54-3.mol

Synonyms:

Chemical Property of 9-[2-(HYDROXYPROPYL-D6)] ADENINE

Chemical Property:

• Melting Point: 194-195°C
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

9-[2-(Hydroxypropyl-d6]Adenine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A deuterated acyclic nucleotide A deuterated acyclic nucleotide.

Technology Process of 9-[2-(HYDROXYPROPYL-D6)] ADENINE

There total 3 articles about 9-[2-(HYDROXYPROPYL-D6)] ADENINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

[D5]-9-(2-oxopropyl)adenine → [D6]-(R)-9-(2-hydroxypropyl)adenine (1020719-54-3)

Guidance literature:

[D₅]-9-(2-oxopropyl)adenine; With potassium dihydrogenphosphate; [D]-sodium hydroxide; 2-Propanol-2-d; ketoreductase P₁B₀₂; water-d2; at 40 ℃; pH=7; Enzymatic reaction;

With potassium carbonate; In 2-methyltetrahydrofuran; at 15 ℃; enantioselective reaction;

DOI:10.1016/j.tetlet.2016.01.087

Reference yield:

[D5]-9-(2-oxopropyl)adenine → [D6]-(S)-9-(2-hydroxypropyl)adenine (1020719-54-3)

Guidance literature:

[D₅]-9-(2-oxopropyl)adenine; With potassium dihydrogenphosphate; [D]-sodium hydroxide; 2-Propanol-2-d; ketoreductase P₂C₀₂; water-d2; at 40 ℃; pH=7; Enzymatic reaction;

With potassium carbonate; In 2-methyltetrahydrofuran; at 15 ℃; enantioselective reaction;

DOI:10.1016/j.tetlet.2016.01.087

Reference yield:

1-(6-amino-9H-purin-9-yl)propan-2-one (105970-02-3) → [D6]-(R)-9-(2-hydroxypropyl)adenine (1020719-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water-d2; deuteromethanol / acetonitrile / 50 °C

2.1: water-d2; 2-Propanol-2-d; [D]-sodium hydroxide; potassium dihydrogenphosphate; ketoreductase P₁B₀₂ / 40 °C / pH 7 / Enzymatic reaction

2.2: 15 °C

With potassium dihydrogenphosphate; [D]-sodium hydroxide; deuteromethanol; 2-Propanol-2-d; ketoreductase P₁B₀₂; water-d2; In acetonitrile;

DOI:10.1016/j.tetlet.2016.01.087

upstream raw materials:

1-(6-amino-9H-purin-9-yl)propan-2-one