(S)-NQ₈₀₁ MTPA ester

Base Information

• Chemical Name: (S)-NQ₈₀₁ MTPA ester
• CAS No.: 1021299-35-3
• Molecular Formula: C₂₄H₁₇F₃O₇
• Molecular Weight: 474.39
• Mol file: 1021299-35-3.mol

Synonyms:

Chemical Property of (S)-NQ₈₀₁ MTPA ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-NQ₈₀₁ MTPA ester

There total 6 articles about (S)-NQ₈₀₁ MTPA ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxynaphtho-1,4-quinone (481-39-0) → (S)-NQ801 MTPA ester (1021299-35-3)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran; toluene / 1.5 h / -40 °C

2: hydrogenchloride; water / 1,4-dioxane / 0.5 h / Heating / reflux

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0 - 20 °C

4: formic acid; triethylamine / (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II) / dichloromethane / 24 h / 20 °C

With hydrogenchloride; formic acid; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

2-Hydroxyjuglon (4923-55-1) → (S)-NQ801 MTPA ester (1021299-35-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0 - 20 °C

2: formic acid; triethylamine / (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II) / dichloromethane / 24 h / 20 °C

With formic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); In tetrahydrofuran; dichloromethane;

Reference yield:

2-(dimethylamino)-5-hydroxy-1,4-naphthalenedione (18512-17-9) → (S)-NQ801 MTPA ester (1021299-35-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; water / 1,4-dioxane / 0.5 h / Heating / reflux

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0 - 20 °C

3: formic acid; triethylamine / (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II) / dichloromethane / 24 h / 20 °C

With hydrogenchloride; formic acid; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); In tetrahydrofuran; 1,4-dioxane; dichloromethane;

upstream raw materials:

(–)-5-hydroxy-2-(1'-hydoxyethyl)naphtho[2,3-b]furan-4,9-dione

5-hydroxynaphtho-1,4-quinone

2-Hydroxyjuglon

2-(dimethylamino)-5-hydroxy-1,4-naphthalenedione