(2S)-6-benzyloxy-2-tert-butyloxycarbonylaminohexanoic acid

Base Information

• Chemical Name: (2S)-6-benzyloxy-2-tert-butyloxycarbonylaminohexanoic acid
• CAS No.: 200405-50-1
• Molecular Formula: C₁₈H₂₇NO₅
• Molecular Weight: 337.416
• Mol file: 200405-50-1.mol

Synonyms:

Chemical Property of (2S)-6-benzyloxy-2-tert-butyloxycarbonylaminohexanoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-6-(phenylmethoxy)-L-norleucine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-6-benzyloxy-2-tert-butyloxycarbonylaminohexanoic acid

There total 1 articles about (2S)-6-benzyloxy-2-tert-butyloxycarbonylaminohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-Amino-6-benzyloxy-hexanoic acid ethyl ester (200405-49-8) → (2S)-6-benzyloxy-2-tert-butyloxycarbonylaminohexanoic acid (200405-50-1)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1016/S0960-894X(97)10084-1

Reference yield:

(2S)-6-benzyloxy-2-tert-butyloxycarbonylaminohexanoic acid (200405-50-1) → (S)-2-tert-Butoxycarbonylamino-6-(toluene-4-sulfonyloxy)-hexanoic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: EDCI, DMAP

2: H₂ / Pd/C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal;

DOI:10.1016/S0960-894X(97)10084-1

Reference yield:

(2S)-6-benzyloxy-2-tert-butyloxycarbonylaminohexanoic acid (200405-50-1) → 3-[(S)-2-tert-Butoxycarbonylamino-6-(toluene-4-sulfonyloxy)-hexanoylamino]-propionic acid methyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: DCC, HOBT

2: H₂ / Pd/C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal;

DOI:10.1016/S0960-894X(97)10084-1

upstream raw materials:

(S)-2-Amino-6-benzyloxy-hexanoic acid ethyl ester

Downstream raw materials:

3-((S)-6-Benzyloxy-2-tert-butoxycarbonylamino-hexanoylamino)-propionic acid methyl ester

(S)-6-Benzyloxy-2-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester