N^α-<6-<ethyl>-N-(benzyloxycarbonyl)amino>methyl>-4-dimethylaminopyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester

Base Information

• Chemical Name: N^α-<6-<ethyl>-N-(benzyloxycarbonyl)amino>methyl>-4-dimethylaminopyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester
• CAS No.: 126769-32-2
• Molecular Formula: C₄₂H₅₄N₈O₉
• Molecular Weight: 814.939

Synonyms:

Chemical Property of N^α-<6-<ethyl>-N-(benzyloxycarbonyl)amino>methyl>-4-dimethylaminopyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N^α-<6-<ethyl>-N-(benzyloxycarbonyl)amino>methyl>-4-dimethylaminopyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester

There total 2 articles about N^α-<6-<ethyl>-N-(benzyloxycarbonyl)amino>methyl>-4-dimethylaminopyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-<ethyl>-N-(benzyloxycarbonyl)amino>methyl>-4-dimethylaminopyridine-2-carboxylate (126794-36-3) → Nα-<6-<ethyl>-N-(benzyloxycarbonyl)amino>methyl>-4-dimethylaminopyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester (126769-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: LiOH / methanol / 1)0 deg C, 30 min 2) r.t., overnight

2: Et₃N, DPPA / dimethylformamide / a)0 deg C, 2 h b) r.t., over night

With lithium hydroxide; diphenyl-phosphinic acid; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)86376-6

Reference yield:

erythro-β-tert-butoxy-L-histidine (101485-30-7,118130-93-1) + 6-{[Benzyloxycarbonyl-((S)-2-benzyloxycarbonylamino-2-carbamoyl-ethyl)-amino]-methyl}-4-dimethylamino-pyridine-2-carboxylic acid → Nα-<6-<ethyl>-N-(benzyloxycarbonyl)amino>methyl>-4-dimethylaminopyridine-2-carbonyl>-erythro-β-tert-butoxy-L-histidine tert-butyl ester (126769-32-2)

Guidance literature:

With diphenyl-phosphinic acid; triethylamine; In N,N-dimethyl-formamide; Yield given; a)0 deg C, 2 h b) r.t., over night;

DOI:10.1016/S0040-4020(01)86376-6

upstream raw materials:

erythro-β-tert-butoxy-L-histidine

methyl 6-<ethyl>-N-(benzyloxycarbonyl)amino>methyl>-4-dimethylaminopyridine-2-carboxylate

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