3-Piperidinecarboxylic acid, 1-[2-(diphenylmethoxy)ethyl]-

Base Information

Chemical Name:3-Piperidinecarboxylic acid, 1-[2-(diphenylmethoxy)ethyl]-
CAS No.:110283-70-0
Molecular Formula:C₂₁H₂₅NO₃
Molecular Weight:339.434
Hs Code.:
DSSTox Substance ID:DTXSID90433944
Nikkaji Number:J376.311K
ChEMBL ID:CHEMBL1191503
Mol file:110283-70-0.mol

Synonyms:CHEMBL542610;110283-70-0;3-Piperidinecarboxylic acid, 1-[2-(diphenylmethoxy)ethyl]-;SCHEMBL9835308;CHEMBL1191503;DTXSID90433944;BDBM50003653;1-[2-(Benzhydryloxy)ethyl]piperidine-3-carboxylic acid;1-(2-Benzhydryloxy-ethyl)-piperidine-3-carboxylic acid;hydrochloride

Suppliers and Price of 3-Piperidinecarboxylic acid, 1-[2-(diphenylmethoxy)ethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Piperidinecarboxylic acid, 1-[2-(diphenylmethoxy)ethyl]-

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:339.18344366
Heavy Atom Count:25
Complexity:384

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CN(C1)CCOC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O

Technology Process of 3-Piperidinecarboxylic acid, 1-[2-(diphenylmethoxy)ethyl]-

There total 4 articles about 3-Piperidinecarboxylic acid, 1-[2-(diphenylmethoxy)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110283-44-8
ethyl 1-<2-(diphenylmethoxy)ethyl>-3-piperidinecarboxylate

: 110283-70-0
1-<2-(diphenylmethoxy)ethyl>-3-piperidinecarboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 4h; Ambient temperature;
DOI:10.1021/jm00064a005

Reference yield:

: 148319-23-7
(+/-)-1-(2-hydroxyethyl)-3-piperidinecarboxylic acid ethyl ester

: 110283-70-0
1-<2-(diphenylmethoxy)ethyl>-3-piperidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / p-toluenesulfonic acid monohydrate / dimethylformamide; toluene / 1.25 h / Heating

2: 12 M aq. NaOH / ethanol / 4 h / Ambient temperature

With sodium hydroxide; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00064a005

Reference yield:

: 91-01-0
1,1-Diphenylmethanol

: 110283-70-0
1-<2-(diphenylmethoxy)ethyl>-3-piperidinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: conc. H₂SO₄ / toluene / 2 h / 85 - 90 °C

2: K₂CO₃ / acetonitrile / 15 h / Heating

3: 2 N aq. LiOH / methanol / 64 h / Ambient temperature

With lithium hydroxide; sulfuric acid; potassium carbonate; In methanol; toluene; acetonitrile;
DOI:10.1021/jm00100a032