(2R,5R)-1-(1,1'-biphenyl-2-yl)-2,5-dimethylphospholane

Base Information

• Chemical Name: (2R,5R)-1-(1,1'-biphenyl-2-yl)-2,5-dimethylphospholane
• CAS No.: 1043508-57-1
• Molecular Formula: C₁₈H₂₁P
• Molecular Weight: 268.338
• Mol file: 1043508-57-1.mol

Synonyms:

Chemical Property of (2R,5R)-1-(1,1'-biphenyl-2-yl)-2,5-dimethylphospholane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2R,5R)-1-(1,1'-biphenyl-2-yl)-2,5-dimethylphospholane

There total 1 articles about (2R,5R)-1-(1,1'-biphenyl-2-yl)-2,5-dimethylphospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S,7S)-4,7-dimethyl-1,3,2-dioxathiepane 2,2-dioxide (220224-82-8) + 1,1'-(biphenyl-2-yl)phosphine (568579-17-9) → (2R,5R)-1-(1,1'-biphenyl-2-yl)-2,5-dimethylphospholane (1043508-57-1)

Guidance literature:

1,1'-(biphenyl-2-yl)phosphine; With potassium tert-butylate; In tetrahydrofuran; at -30 - 0 ℃; for 1h;

(4S,7S)-4,7-dimethyl-1,3,2-dioxathiepane 2,2-dioxide; In tetrahydrofuran; at 20 ℃; for 2h;

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 48h; Further stages.;

DOI:10.1021/jo800969x

upstream raw materials:

(4S,7S)-4,7-dimethyl-1,3,2-dioxathiepane 2,2-dioxide

1,1'-(biphenyl-2-yl)phosphine