1-(4-fluorophenyl)-4-((1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl)methylamino)-1-butanone

Base Information

• Chemical Name: 1-(4-fluorophenyl)-4-((1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl)methylamino)-1-butanone
• CAS No.: 132427-62-4
• Molecular Formula: C₃₀H₄₀FNO
• Molecular Weight: 449.652
• Mol file: 132427-62-4.mol

Synonyms:

Chemical Property of 1-(4-fluorophenyl)-4-((1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl)methylamino)-1-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-fluorophenyl)-4-((1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl)methylamino)-1-butanone

There total 3 articles about 1-(4-fluorophenyl)-4-((1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl)methylamino)-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{3-[2-(4-Fluoro-phenyl)-5,5-dimethyl-[1,3]dioxan-2-yl]-propyl}-((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-ylmethyl)-amine (132428-17-2) → 1-(4-fluorophenyl)-4-((1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl)methylamino)-1-butanone (132427-62-4)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1016/0223-5234(91)90116-5

Reference yield:

leelamine (1446-61-3,104530-67-8,1416-08-6,24564-18-9,27174-94-3,66989-22-8,87926-74-7,25512-83-8) → 1-(4-fluorophenyl)-4-((1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl)methylamino)-1-butanone (132427-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, KI / dimethylformamide / 24 h / Heating

2: conc HCl / methanol

With hydrogenchloride; potassium carbonate; potassium iodide; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(91)90116-5

Reference yield:

(chloro-3 propyl)-2 (fluoro-4 phenyl)-2 dimethyl-5,5 dioxanne-1,3 (36714-65-5) → 1-(4-fluorophenyl)-4-((1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl)methylamino)-1-butanone (132427-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, KI / dimethylformamide / 24 h / Heating

2: conc HCl / methanol

With hydrogenchloride; potassium carbonate; potassium iodide; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(91)90116-5

upstream raw materials:

{3-[2-(4-Fluoro-phenyl)-5,5-dimethyl-[1,3]dioxan-2-yl]-propyl}-((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-ylmethyl)-amine

leelamine

(chloro-3 propyl)-2 (fluoro-4 phenyl)-2 dimethyl-5,5 dioxanne-1,3