3-(2-iodophenyl)-N-methoxy-N-phenylpropanamide

Base Information

• Chemical Name: 3-(2-iodophenyl)-N-methoxy-N-phenylpropanamide
• CAS No.: 1402345-55-4
• Molecular Formula: C₁₆H₁₆INO₂
• Molecular Weight: 381.213
• Mol file: 1402345-55-4.mol

Synonyms:

Chemical Property of 3-(2-iodophenyl)-N-methoxy-N-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-iodophenyl)-N-methoxy-N-phenylpropanamide

There total 5 articles about 3-(2-iodophenyl)-N-methoxy-N-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

iodobenzene (591-50-4) + 3-(2-iodophenyl)-N-methoxypropanamide (1402345-89-4) → 3-(2-iodophenyl)-N-methoxy-N-phenylpropanamide (1402345-55-4) + N-methoxy-3,4-dihydro-1H-quinolin-2-one (91523-37-4)

Guidance literature:

With copper(I) oxide; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 80 ℃; for 18h; Inert atmosphere; Molecular sieve;

DOI:10.1055/s-0031-1290384

Reference yield:

methyl 3-(2-iodophenyl)propanoate (141273-91-8) → 3-(2-iodophenyl)-N-methoxy-N-phenylpropanamide (1402345-55-4) + N-methoxy-3,4-dihydro-1H-quinolin-2-one (91523-37-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 2 h / Reflux

1.2: pH 2

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

3.1: copper(I) oxide; potassium carbonate; N,N`-dimethylethylenediamine / toluene / 18 h / 80 °C / Inert atmosphere; Molecular sieve

With copper(I) oxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; N,N`-dimethylethylenediamine; In ethanol; dichloromethane; water; toluene;

DOI:10.1055/s-0031-1290384

Reference yield:

3-(2-bromophenyl)propanoic acid,methyl ester (66191-86-4) → 3-(2-iodophenyl)-N-methoxy-N-phenylpropanamide (1402345-55-4) + N-methoxy-3,4-dihydro-1H-quinolin-2-one (91523-37-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 36 h / 120 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol; water / 2 h / Reflux

2.2: pH 2

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

4.1: copper(I) oxide; potassium carbonate; N,N`-dimethylethylenediamine / toluene / 18 h / 80 °C / Inert atmosphere; Molecular sieve

With copper(I) oxide; copper(l) iodide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium iodide; sodium hydroxide; N,N`-dimethylethylenediamine; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;

DOI:10.1055/s-0031-1290384

upstream raw materials:

methyl 3-(2-iodophenyl)propanoate

iodobenzene

3-(2-iodophenyl)-N-methoxypropanamide

3-(2-bromophenyl)propanoic acid,methyl ester