Technology Process of 10,11,14,15-13C4-retinoic acid ethyl ester
There total 5 articles about 10,11,14,15-13C4-retinoic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 99 percent / NaH / diethyl ether
2.1: 99 percent / LiAlH4 / diethyl ether
3.1: 92 percent / MnO2 / hexane
4.1: aq. NaOH / 6 h
4.2: 90 percent / SiO2 / ethyl acetate; hexane
5.1: 0.8 g / NaH / diethyl ether
With
manganese(IV) oxide; sodium hydroxide; lithium aluminium tetrahydride; sodium hydride;
In
diethyl ether; hexane;
1.1: Wittig-Horner reaction / 5.1: Wittig-Horner reaction;
DOI:10.1002/jlcr.464
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: aq. NaOH / 6 h
1.2: 90 percent / SiO2 / ethyl acetate; hexane
2.1: 0.8 g / NaH / diethyl ether
With
sodium hydroxide; sodium hydride;
In
diethyl ether;
2.1: Wittig-Horner reaction;
DOI:10.1002/jlcr.464
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 92 percent / MnO2 / hexane
2.1: aq. NaOH / 6 h
2.2: 90 percent / SiO2 / ethyl acetate; hexane
3.1: 0.8 g / NaH / diethyl ether
With
manganese(IV) oxide; sodium hydroxide; sodium hydride;
In
diethyl ether; hexane;
3.1: Wittig-Horner reaction;
DOI:10.1002/jlcr.464
