N,N,N-tributyl-1-butanaminium 1,4:3,6-dianhydro-2-O-benzyl-D-glucidylphosphorofluoridate

Base Information

• Chemical Name: N,N,N-tributyl-1-butanaminium 1,4:3,6-dianhydro-2-O-benzyl-D-glucidylphosphorofluoridate
• CAS No.: 1334123-78-2
• Molecular Formula: C₁₃H₁₅FO₆P*C₁₆H₃₆N
• Molecular Weight: 559.699
• Mol file: 1334123-78-2.mol

Synonyms:

Chemical Property of N,N,N-tributyl-1-butanaminium 1,4:3,6-dianhydro-2-O-benzyl-D-glucidylphosphorofluoridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N,N-tributyl-1-butanaminium 1,4:3,6-dianhydro-2-O-benzyl-D-glucidylphosphorofluoridate

There total 2 articles about N,N,N-tributyl-1-butanaminium 1,4:3,6-dianhydro-2-O-benzyl-D-glucidylphosphorofluoridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

phosphoric acid 1,4:3,6-dianhydro-2-O-benzyl-D-glucidyl diphenyl ester (1334123-64-6) + tetrabutyl ammonium fluoride (429-41-4) → N,N,N-tributyl-1-butanaminium 1,4:3,6-dianhydro-2-O-benzyl-D-glucidylphosphorofluoridate (1334123-78-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 7h; Inert atmosphere;

DOI:10.1002/hc.20700

Reference yield:

(3R,3aR,6S,6aR)-6-(Benzyloxy)hexahydrofuro[3,2-b]furan-3-ol (111956-66-2) → N,N,N-tributyl-1-butanaminium 1,4:3,6-dianhydro-2-O-benzyl-D-glucidylphosphorofluoridate (1334123-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / dichloromethane / 5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 7 h / 20 °C / Inert atmosphere

With dmap; In tetrahydrofuran; dichloromethane;

DOI:10.1002/hc.20700

upstream raw materials:

phosphoric acid 1,4:3,6-dianhydro-2-O-benzyl-D-glucidyl diphenyl ester

tetrabutyl ammonium fluoride

(3R,3aR,6S,6aR)-6-(Benzyloxy)hexahydrofuro[3,2-b]furan-3-ol