C₂₃H₁₈F₂N₆O₃

Base Information

• Chemical Name: C₂₃H₁₈F₂N₆O₃
• CAS No.: 1333991-97-1
• Molecular Formula: C₂₃H₁₈F₂N₆O₃
• Molecular Weight: 464.431
• Mol file: 1333991-97-1.mol

Synonyms:

Chemical Property of C₂₃H₁₈F₂N₆O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₁₈F₂N₆O₃

There total 10 articles about C₂₃H₁₈F₂N₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-5-(aminomethyl)-3-(3-fluorophenyl)oxazolidin-2-one (380380-56-3) → C23H18F2N6O3 (1333991-97-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: iodine; silver trifluoroacetate / chloroform; acetonitrile

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; In dichloromethane; chloroform; acetonitrile; 3: Suzuki coupling reaction;

DOI:10.1016/j.bmcl.2011.07.034

Reference yield:

[(5R)-3-(3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl methanesulfonate (380380-55-2) → C23H18F2N6O3 (1333991-97-1)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium azide / N,N-dimethyl-formamide / 70 °C

2: triphenylphosphine / tetrahydrofuran; water / 50 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: iodine; silver trifluoroacetate / chloroform; acetonitrile

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium azide; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; 5: Suzuki coupling reaction;

DOI:10.1016/j.bmcl.2011.07.034

Reference yield:

(R)-[3-(3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl azide (149524-44-7) → C23H18F2N6O3 (1333991-97-1)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine / tetrahydrofuran; water / 50 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: iodine; silver trifluoroacetate / chloroform; acetonitrile

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; chloroform; water; acetonitrile; 4: Suzuki coupling reaction;

DOI:10.1016/j.bmcl.2011.07.034

upstream raw materials:

[(5R)-3-(3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl methanesulfonate

(R)-[3-(3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl azide

(S)-5-(aminomethyl)-3-(3-fluorophenyl)oxazolidin-2-one

C₁₁H₈BrFN₄