1-Phenyl-2-ethynyl-3-tert-butoxycarbonylaziridine

Base Information

• Chemical Name: 1-Phenyl-2-ethynyl-3-tert-butoxycarbonylaziridine
• CAS No.: 90404-05-0
• Molecular Formula: C₁₅H₁₇NO₂
• Molecular Weight: 243.305
• Mol file: 90404-05-0.mol

Synonyms:

Chemical Property of 1-Phenyl-2-ethynyl-3-tert-butoxycarbonylaziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Phenyl-2-ethynyl-3-tert-butoxycarbonylaziridine

There total 2 articles about 1-Phenyl-2-ethynyl-3-tert-butoxycarbonylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

tert-Butyl chloroacetate (107-59-5) + N-Propynylideneaniline (90404-04-9) → 1-Phenyl-2-ethynyl-3-tert-butoxycarbonylaziridine (90404-05-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; 1) -40 deg C, 5 h, 2) room temp., 5 h.;

DOI:10.1007/BF00506283

Reference yield:

aniline (62-53-3) → 1-Phenyl-2-ethynyl-3-tert-butoxycarbonylaziridine (90404-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 31 percent / acetic acid / diethyl ether / 1 h / -40 °C

2: 45 percent / potassium tert-butoxide / tetrahydrofuran / 1) -40 deg C, 5 h, 2) room temp., 5 h.

With potassium tert-butylate; acetic acid; In tetrahydrofuran; diethyl ether;

DOI:10.1007/BF00506283

upstream raw materials:

tert-Butyl chloroacetate

N-Propynylideneaniline

aniline