methyl (3S)-3-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-({(2S)-3-methyl-1-oxo-1-[(2-phenylethyl)amino]butan-2-yl}amino)-4-oxobutanoate

Base Information

• Chemical Name: methyl (3S)-3-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-({(2S)-3-methyl-1-oxo-1-[(2-phenylethyl)amino]butan-2-yl}amino)-4-oxobutanoate
• CAS No.: 1372701-06-8
• Molecular Formula: C₄₁H₅₄N₆O₇
• Molecular Weight: 742.916

Synonyms:

Chemical Property of methyl (3S)-3-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-({(2S)-3-methyl-1-oxo-1-[(2-phenylethyl)amino]butan-2-yl}amino)-4-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (3S)-3-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-({(2S)-3-methyl-1-oxo-1-[(2-phenylethyl)amino]butan-2-yl}amino)-4-oxobutanoate

There total 11 articles about methyl (3S)-3-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-({(2S)-3-methyl-1-oxo-1-[(2-phenylethyl)amino]butan-2-yl}amino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C2HF3O2*C17H24N2O5 (1292797-85-3) → methyl (3S)-3-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-({(2S)-3-methyl-1-oxo-1-[(2-phenylethyl)amino]butan-2-yl}amino)-4-oxobutanoate (1372701-06-8)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane

2: dichloromethane / 2 h

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

4: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.10.078

Reference yield:

C22H32N2O7 (1292797-86-4) → methyl (3S)-3-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-({(2S)-3-methyl-1-oxo-1-[(2-phenylethyl)amino]butan-2-yl}amino)-4-oxobutanoate (1372701-06-8)

Guidance literature:

Multi-step reaction with 6 steps

1: dichloromethane / 2 h

2: triethylamine / dichloromethane

3: dichloromethane / 2 h

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

5: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

6: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.10.078

Reference yield:

C2HF3O2*C23H35N3O6 (1292797-88-6) → methyl (3S)-3-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-({(2S)-3-methyl-1-oxo-1-[(2-phenylethyl)amino]butan-2-yl}amino)-4-oxobutanoate (1372701-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

2: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.10.078

upstream raw materials:

C₂₂H₃₂N₂O₇

C₂HF₃O₂*C₁₇H₂₄N₂O₅

C₂₈H₄₃N₃O₈

C₂HF₃O₂*C₂₃H₃₅N₃O₆

Downstream raw materials:

N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-(2-phenylethyl)-L-valinamide

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