(E)-(3-(3-fluorophenyl)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo-[4,3-a]pyridin-3-yl)methanol

Base Information

Chemical Name:(E)-(3-(3-fluorophenyl)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo-[4,3-a]pyridin-3-yl)methanol
CAS No.:1352129-94-2
Molecular Formula:C₂₅H₂₅FN₄O₃
Molecular Weight:448.497
Hs Code.:

(E)-(3-(3-fluorophenyl)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo-[4,3-a]pyridin-3-yl)methanol

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Chemical Property of (E)-(3-(3-fluorophenyl)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo-[4,3-a]pyridin-3-yl)methanol

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Technology Process of (E)-(3-(3-fluorophenyl)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo-[4,3-a]pyridin-3-yl)methanol

There total 4 articles about (E)-(3-(3-fluorophenyl)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo-[4,3-a]pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1226632-05-8
C₂₇H₂₇FN₄O₄

: 1352129-94-2
(E)-(3-(3-fluorophenyl)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo-[4,3-a]pyridin-3-yl)methanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 2h; Cooling with ice;
DOI:10.1021/jm201407j

Reference yield:

: 1352130-05-2
C₁₃H₁₅BrFNO₂

: 1352129-94-2
(E)-(3-(3-fluorophenyl)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo-[4,3-a]pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / N,N-dimethyl-formamide / -10 - 20 °C

2: potassium tert-butylate / tetrahydrofuran / -70 - 12 °C / Inert atmosphere

3: potassium tert-butylate / tetrahydrofuran / -78 - -20 °C / Inert atmosphere

4: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; potassium tert-butylate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm201407j

Reference yield:

: 1352130-14-3
C₁₉H₂₇BrFN₂O₆P

: 1352129-94-2
(E)-(3-(3-fluorophenyl)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo-[4,3-a]pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / -70 - 12 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / -78 - -20 °C / Inert atmosphere

3: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; potassium tert-butylate; In tetrahydrofuran; methanol; 2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm201407j