(R)-3-amino-4-(biphenyl-4-yl)-1-((R)-3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one trifluoroacetate

Base Information

Chemical Name:(R)-3-amino-4-(biphenyl-4-yl)-1-((R)-3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one trifluoroacetate
CAS No.:1365884-69-0
Molecular Formula:C₂HF₃O₂*C₃₂H₃₇ClN₄O₂
Molecular Weight:659.148
Hs Code.:

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Chemical Property of (R)-3-amino-4-(biphenyl-4-yl)-1-((R)-3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one trifluoroacetate

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Technology Process of (R)-3-amino-4-(biphenyl-4-yl)-1-((R)-3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one trifluoroacetate

There total 11 articles about (R)-3-amino-4-(biphenyl-4-yl)-1-((R)-3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365884-68-9
tert-butyl (R)-1-(biphenyl-4-yl)-4-((R)-3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-ylcarbamate

: 76-05-1
trifluoroacetic acid

: 1365884-69-0
(R)-3-amino-4-(biphenyl-4-yl)-1-((R)-3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one trifluoroacetate

Guidance literature:: In dichloromethane; for 4h; Inert atmosphere;

Reference yield:

: 59483-54-4
3-chloro-2-nitro-aniline

: 1365884-69-0
(R)-3-amino-4-(biphenyl-4-yl)-1-((R)-3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc; acetic acid / methanol / 20 °C / Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C

2.2: 3 h / 80 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / Inert atmosphere

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

5.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.25 h / 120 °C / Microwave irradiation

6.1: dichloromethane / 4 h / Inert atmosphere

With 4-methyl-morpholine; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; trifluoroacetic acid; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 331763-75-8
(R)-4-(4-bromophenyl)-3-((tert-butoxycarbonyl)amino)butanoic acid

: 1365884-69-0
(R)-3-amino-4-(biphenyl-4-yl)-1-((R)-3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.25 h / 120 °C / Microwave irradiation

3: dichloromethane / 4 h / Inert atmosphere

With 4-methyl-morpholine; sodium carbonate; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;