(5S,6S)-3-(2-Amino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7,7-dimethoxy-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester

Base Information

Chemical Name:(5S,6S)-3-(2-Amino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7,7-dimethoxy-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester
CAS No.:97517-01-6
Molecular Formula:C₂₇H₃₃NO₅S
Molecular Weight:483.629
Hs Code.:

Synonyms:

Suppliers and Price of (5S,6S)-3-(2-Amino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7,7-dimethoxy-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,6S)-3-(2-Amino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7,7-dimethoxy-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,6S)-3-(2-Amino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7,7-dimethoxy-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester

There total 12 articles about (5S,6S)-3-(2-Amino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7,7-dimethoxy-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97517-25-4
silyloxyfulvene

: 97517-01-6,97589-24-7
(5S,6S)-3-(2-Amino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7,7-dimethoxy-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 11 steps

1: Et₃N / cyclohexane / 1.5 h / Ambient temperature

2: 34 percent / 50 percent HF / acetonitrile / 0.58 h / Heating

3: Jones reagent / acetone / 0.75 h / 20 °C

4: ethyl acetate / 1 h / Ambient temperature

5: Zn / tetrahydrofuran; acetic acid / 6 h / Ambient temperature

6: Et₃N / tetrahydrofuran / 1 h / Ambient temperature

7: SO₂Cl₂, pyridine / CH₂Cl₂ / 0.5 h / -60 °C

8: LiN(SiMe₃)2, Cp₂ZrCl₂ / tetrahydrofuran / 1 h / 1.) -78 deg C, 2.) 0 deg C

9: H ⁽¹⁺⁾ / methanol; tetrahydrofuran / 1 h / Heating

10: 82 percent / MCPBA / CH₂Cl₂ / 1.5 h / Heating

11: methanol; tetrahydrofuran / 0.25 h / Ambient temperature

With pyridine; sulfuryl dichloride; jones reagent; zirconocene dichloride; hydrogen fluoride; hydrogen cation; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; acetic acid; ethyl acetate; acetone; acetonitrile;
DOI:10.1016/S0040-4039(00)98208-X

Reference yield:

: 97517-24-3
6,6-Dichloro-7-oxobicyclo[3.2.0]hept-2-en-2-carboxaldehyde

: 97517-01-6,97589-24-7
(5S,6S)-3-(2-Amino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7,7-dimethoxy-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 9 steps

1: Jones reagent / acetone / 0.75 h / 20 °C

2: ethyl acetate / 1 h / Ambient temperature

3: Zn / tetrahydrofuran; acetic acid / 6 h / Ambient temperature

4: Et₃N / tetrahydrofuran / 1 h / Ambient temperature

5: SO₂Cl₂, pyridine / CH₂Cl₂ / 0.5 h / -60 °C

6: LiN(SiMe₃)2, Cp₂ZrCl₂ / tetrahydrofuran / 1 h / 1.) -78 deg C, 2.) 0 deg C

7: H ⁽¹⁺⁾ / methanol; tetrahydrofuran / 1 h / Heating

8: 82 percent / MCPBA / CH₂Cl₂ / 1.5 h / Heating

9: methanol; tetrahydrofuran / 0.25 h / Ambient temperature

With pyridine; sulfuryl dichloride; jones reagent; zirconocene dichloride; hydrogen cation; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; dichloromethane; acetic acid; ethyl acetate; acetone;
DOI:10.1016/S0040-4039(00)98208-X

Reference yield:

: 97517-23-2
4-[1-(tert-Butyl-dimethyl-silanyloxy)-meth-(E)-ylidene]-7,7-dichloro-bicyclo[3.2.0]hept-2-en-6-one

: 97517-01-6,97589-24-7
(5S,6S)-3-(2-Amino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7,7-dimethoxy-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 34 percent / 50 percent HF / acetonitrile / 0.58 h / Heating

2: Jones reagent / acetone / 0.75 h / 20 °C

3: ethyl acetate / 1 h / Ambient temperature

4: Zn / tetrahydrofuran; acetic acid / 6 h / Ambient temperature

5: Et₃N / tetrahydrofuran / 1 h / Ambient temperature

6: SO₂Cl₂, pyridine / CH₂Cl₂ / 0.5 h / -60 °C

7: LiN(SiMe₃)2, Cp₂ZrCl₂ / tetrahydrofuran / 1 h / 1.) -78 deg C, 2.) 0 deg C

8: H ⁽¹⁺⁾ / methanol; tetrahydrofuran / 1 h / Heating

9: 82 percent / MCPBA / CH₂Cl₂ / 1.5 h / Heating

10: methanol; tetrahydrofuran / 0.25 h / Ambient temperature

With pyridine; sulfuryl dichloride; jones reagent; zirconocene dichloride; hydrogen fluoride; hydrogen cation; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; dichloromethane; acetic acid; ethyl acetate; acetone; acetonitrile;
DOI:10.1016/S0040-4039(00)98208-X