6-Fluoro-N,N-diethyltryptamine

Base Information

• Chemical Name: 6-Fluoro-N,N-diethyltryptamine
• CAS No.: 2836-69-3
• Molecular Formula: C₁₄H₁₉FN₂
• Molecular Weight: 234.317
• UNII: 0ZD2XR6YPV
• DSSTox Substance ID: DTXSID301345652
• Nikkaji Number: J1.474.867I
• Wikidata: Q110782354
• ChEMBL ID: CHEMBL444612
• Mol file: 2836-69-3.mol

Synonyms:6-fluoro-N,N-diethyltryptamine

Chemical Property of 6-Fluoro-N,N-diethyltryptamine

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 234.15322678
• Heavy Atom Count: 17
• Complexity: 230

Purity/Quality:

99% ^*data from raw suppliers

6-fluoro DET ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(CC)CCC1=CNC2=C1C=CC(=C2)F
• Description: 6-fluoro DET (Item No. 20834) is an analytical reference standard categorized as a tryptamine. This product is intended for research and forensic applications.

Technology Process of 6-Fluoro-N,N-diethyltryptamine

There total 8 articles about 6-Fluoro-N,N-diethyltryptamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N,N-diethyl-6-fluoroindol-3-ylglyoxalylamide (1548-90-9) → 6-fluoro N,N-Diethyltryptamine (2836-69-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Heating;

DOI:10.1021/jm000339w

Reference yield:

6-fluoro-1H-indole (399-51-9) → 6-fluoro N,N-Diethyltryptamine (2836-69-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 5 h / 20 °C

2: 55.4 percent / diethyl ether

3: 67 percent / LiAlH₄ / tetrahydrofuran / 6 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm000339w

Reference yield:

6-fluoro-1H-indole-2-carboxylic acid (3093-97-8) → 6-fluoro N,N-Diethyltryptamine (2836-69-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / Cu; N-methylpyrrolidinone / 6 h / 240 - 250 °C

2: diethyl ether / 5 h / 20 °C

3: 55.4 percent / diethyl ether

4: 67 percent / LiAlH₄ / tetrahydrofuran / 6 h / Heating

With 1-methyl-pyrrolidin-2-one; lithium aluminium tetrahydride; copper; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm000339w

upstream raw materials:

N,N-diethyl-6-fluoroindol-3-ylglyoxalylamide

6-fluoro-1H-indole

6-fluoro-1H-indole-2-carboxylic acid

4-fluorobenzaldehyde