1-(4-((R)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

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Chemical Name:1-(4-((R)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
CAS No.:1260091-77-7
Molecular Formula:C₂₄H₃₁N₅O₄
Molecular Weight:453.541
Hs Code.:

Synonyms:

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Chemical Property of 1-(4-((R)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

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Technology Process of 1-(4-((R)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

There total 8 articles about 1-(4-((R)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₉N₅O₄

: 1260091-76-6
1-(4-((S)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

: 1260091-77-7
1-(4-((R)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Guidance literature:: C₂₄H₂₉N₅O₄; With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 0.5h; Cooling with ice;

With ammonium chloride; In tetrahydrofuran; water;
DOI:10.1021/jm200215y

Reference yield:

: C₂₅H₃₃N₅O₅

: 1260091-76-6
1-(4-((S)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

: 1260091-77-7
1-(4-((R)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate / tetrahydrofuran; water / 1.5 h / 20 °C

2: methanol; sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

With methanol; sodium tetrahydroborate; sodium periodate; In tetrahydrofuran; water;
DOI:10.1021/jm200215y

Reference yield:

: 1260090-21-8
(+/-)-ethyl 5-allyl-4-amino-5-methyl-2,5-dihydrofuran-3-carboxylate

: 1260091-76-6
1-(4-((S)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

: 1260091-77-7
1-(4-((R)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 1,2-dichloro-ethane; toluene / 2.17 h / 0 - 20 °C

1.2: 0 - 50 °C

2.1: trichlorophosphate / 1,2-dichloro-ethane / 90 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 0 °C

4.1: potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / water; acetonitrile / 90 °C

5.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 48 h / 20 °C

6.1: sodium periodate / tetrahydrofuran; water / 1.5 h / 20 °C

7.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

With pyridine; methanol; sodium tetrahydroborate; potassium phosphate; sodium periodate; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; trichlorophosphate; tricyclohexylphosphine; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm200215y