2-cyanoethyl 3'-O-[5'-O-(4'',4'''-dimethoxytrityl)]thymidinyl-5'-C-2''-tosyloxyethyl-3'-(tert-butyldiphenylsilyl)thymidinyl phosphoric ester

Base Information

Chemical Name:2-cyanoethyl 3'-O-[5'-O-(4'',4'''-dimethoxytrityl)]thymidinyl-5'-C-2''-tosyloxyethyl-3'-(tert-butyldiphenylsilyl)thymidinyl phosphoric ester
CAS No.:927687-49-8
Molecular Formula:C₆₉H₇₆N₅O₁₇PSSi
Molecular Weight:1338.51
Hs Code.:

2-cyanoethyl 3'-O-[5'-O-(4'',4'''-dimethoxytrityl)]thymidinyl-5'-C-2''-tosyloxyethyl-3'-(tert-butyldiphenylsilyl)thymidinyl phosphoric ester

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Chemical Property of 2-cyanoethyl 3'-O-[5'-O-(4'',4'''-dimethoxytrityl)]thymidinyl-5'-C-2''-tosyloxyethyl-3'-(tert-butyldiphenylsilyl)thymidinyl phosphoric ester

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Technology Process of 2-cyanoethyl 3'-O-[5'-O-(4'',4'''-dimethoxytrityl)]thymidinyl-5'-C-2''-tosyloxyethyl-3'-(tert-butyldiphenylsilyl)thymidinyl phosphoric ester

There total 4 articles about 2-cyanoethyl 3'-O-[5'-O-(4'',4'''-dimethoxytrityl)]thymidinyl-5'-C-2''-tosyloxyethyl-3'-(tert-butyldiphenylsilyl)thymidinyl phosphoric ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₉H₇₆N₅O₁₆PSSi

: 927687-49-8
2-cyanoethyl 3'-O-[5'-O-(4'',4'''-dimethoxytrityl)]thymidinyl-5'-C-2''-tosyloxyethyl-3'-(tert-butyldiphenylsilyl)thymidinyl phosphoric ester

Guidance literature:: With 2,3,5-trimethyl-pyridine; iodine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1002/ejoc.200600593

Reference yield:

: C₃₅H₄₀N₂O₈SSi

: 927687-49-8
2-cyanoethyl 3'-O-[5'-O-(4'',4'''-dimethoxytrityl)]thymidinyl-5'-C-2''-tosyloxyethyl-3'-(tert-butyldiphenylsilyl)thymidinyl phosphoric ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / ethanol / 0 °C

2: tetrazole / acetonitrile / 20 °C

3: collidine; I₂ / acetonitrile; tetrahydrofuran; H₂O

With 1H-tetrazole; 2,3,5-trimethyl-pyridine; sodium tetrahydroborate; iodine; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1002/ejoc.200600593

Reference yield:

: 3'-O-tert-butyldiphenylsilyl-5'-C-(2''-tosyloxyethyl)thymidine

: 927687-49-8
2-cyanoethyl 3'-O-[5'-O-(4'',4'''-dimethoxytrityl)]thymidinyl-5'-C-2''-tosyloxyethyl-3'-(tert-butyldiphenylsilyl)thymidinyl phosphoric ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole / acetonitrile / 20 °C

2: collidine; I₂ / acetonitrile; tetrahydrofuran; H₂O

With 1H-tetrazole; 2,3,5-trimethyl-pyridine; iodine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1002/ejoc.200600593