2,2-Dimethylindoline

Base Information

• Chemical Name: 2,2-Dimethylindoline
• CAS No.: 18023-30-8
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• European Community (EC) Number: 882-687-4
• Nikkaji Number: J1.632.739E
• Mol file: 18023-30-8.mol

Synonyms:2,2-DIMETHYLINDOLINE;18023-30-8;2,2-DIMETHYL-2,3-DIHYDRO-1H-INDOLE;2,2-dimethyl-1,3-dihydroindole;1H-Indole, 2,3-dihydro-2,2-dimethyl-;SCHEMBL1119036;RXCOLBXGORCBMP-UHFFFAOYSA-N;AB70011;CS-0246304;EN300-321840

Chemical Property of 2,2-Dimethylindoline

Chemical Property:

• Melting Point: 138 °C
• Boiling Point: 90-92 °C(Press: 13 Torr)
• PKA: 5.33±0.40(Predicted)
• Density: 0.962±0.06 g/cm3(Predicted)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 147.104799419
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

99% ^*data from raw suppliers

2,2-Dimethylindoline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC2=CC=CC=C2N1)C

Technology Process of 2,2-Dimethylindoline

There total 5 articles about 2,2-Dimethylindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2,2-dimethyl-1,2-dihydro-3H-indol-3-one (3929-78-0) → 2,2-dimethyl-2,3-dihydro-1H-indole (18023-30-8)

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

1-acetyl-2,2-dimethyl-2,3-dihydroindol-3-one (153278-96-7) → 2,2-dimethyl-2,3-dihydro-1H-indole (18023-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 1 h / 100 °C

2: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 2 h / 0 - 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; sodium hydroxide; In tetrahydrofuran; ethanol;

Reference yield:

2-isopropylaminobenzyl alcohol (106898-71-9) → 2,2-dimethyl-2,3-dihydro-1H-indole (18023-30-8)

Guidance literature:

upstream raw materials:

2-isopropylaminobenzyl alcohol

2,2-dimethyl-1,2-dihydro-3H-indol-3-one

1-acetyl-2,2-dimethyl-2,3-dihydroindol-3-one