Technology Process of DL-2,3,4,5,6-penta-O-benzoyl-myo-inositol 1-<(S)-3,4-bis(palmitoyloxy)butanesulfonate>
There total 12 articles about DL-2,3,4,5,6-penta-O-benzoyl-myo-inositol 1-<(S)-3,4-bis(palmitoyloxy)butanesulfonate> which
guide to synthetic route it.
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synthetic route:
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134275-55-1,141899-75-4,141899-80-1
Hexadecanoic acid 1-hexadecanoyloxymethyl-3-((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyloxysulfonyl)-propyl ester
- Guidance literature:
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Multi-step reaction with 9 steps
1: NaH / dimethylformamide
2: 71 percent / aq. HOAc
3: 1) Bu2SnO, 2) CsF / 1) MeOH, 2) DMF
4: 88 percent / NaH / dimethylformamide
5: 95 percent / p-TsOH / Pd-C / methanol; H2O / Heating
6: 85 percent / pyridine / CH2Cl2
7: 1) BuLi / 1) n-hexane, THF, -78 deg C, 2) THF, a) 1 h, -78 deg C, b) 2 h, r.t.
8: aq. HOAc
9: pyridine / CH2Cl2
With
pyridine; n-butyllithium; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; acetic acid; cesium fluoride;
palladium on activated charcoal;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
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10583-42-3,64681-25-0,64681-27-2,64681-28-3,111466-10-5,111466-15-0,132437-50-4,132437-54-8,135267-01-5,135355-09-8,138923-08-7,138923-09-8,144068-89-3
(+/-)-1-O-allyl-3,4,5,6-tetrakis-O-benzyl myo-inositol
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134275-55-1,141899-75-4,141899-80-1
Hexadecanoic acid 1-hexadecanoyloxymethyl-3-((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyloxysulfonyl)-propyl ester
- Guidance literature:
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Multi-step reaction with 6 steps
1: 88 percent / NaH / dimethylformamide
2: 95 percent / p-TsOH / Pd-C / methanol; H2O / Heating
3: 85 percent / pyridine / CH2Cl2
4: 1) BuLi / 1) n-hexane, THF, -78 deg C, 2) THF, a) 1 h, -78 deg C, b) 2 h, r.t.
5: aq. HOAc
6: pyridine / CH2Cl2
With
pyridine; n-butyllithium; sodium hydride; toluene-4-sulfonic acid; acetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
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134275-55-1,141899-75-4,141899-80-1
Hexadecanoic acid 1-hexadecanoyloxymethyl-3-((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyloxysulfonyl)-propyl ester
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / p-TsOH / Pd-C / methanol; H2O / Heating
2: 85 percent / pyridine / CH2Cl2
3: 1) BuLi / 1) n-hexane, THF, -78 deg C, 2) THF, a) 1 h, -78 deg C, b) 2 h, r.t.
4: aq. HOAc
5: pyridine / CH2Cl2
With
pyridine; n-butyllithium; toluene-4-sulfonic acid; acetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane; water;
