[(S)-1-((S)-1-{(S)-1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid isopropyl ester

Base Information

Chemical Name:[(S)-1-((S)-1-{(S)-1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid isopropyl ester
CAS No.:628729-14-6
Molecular Formula:C₃₂H₄₆N₄O₆
Molecular Weight:582.74
Hs Code.:

[(S)-1-((S)-1-{(S)-1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid isopropyl ester

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Chemical Property of [(S)-1-((S)-1-{(S)-1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid isopropyl ester

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Technology Process of [(S)-1-((S)-1-{(S)-1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid isopropyl ester

There total 8 articles about [(S)-1-((S)-1-{(S)-1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2462-34-2
L-valine benzyl ester hydrochloride

: 628729-14-6
[(S)-1-((S)-1-{(S)-1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid isopropyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: i-Pr₂EtN

2: 100 percent / H₂ / Pd/C

3: 78 percent / HOAt; DCC; i-Pr₂EtN

4: 93 percent / aq. NaOH / methanol

5: PyBOP; i-Pr₂EtN

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol;
DOI:10.1016/S0960-894X(03)00753-4

Reference yield:

: 628729-15-7
(S)-2-Isopropoxycarbonylamino-3-methyl-butyric acid benzyl ester

: 628729-14-6
[(S)-1-((S)-1-{(S)-1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid isopropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / Pd/C

2: 78 percent / HOAt; DCC; i-Pr₂EtN

3: 93 percent / aq. NaOH / methanol

4: PyBOP; i-Pr₂EtN

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol;
DOI:10.1016/S0960-894X(03)00753-4

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 628729-14-6
[(S)-1-((S)-1-{(S)-1-[Hydroxy-((S)-1-phenyl-ethylcarbamoyl)-methyl]-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PyBOP

2: 100 percent / H₂ / Pd(OH)2/C

3: PyBOP; i-Pr₂EtN

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide;
DOI:10.1016/S0960-894X(03)00753-4