Technology Process of (+/-)-2,3-dihydro-1--2-thioxo-4(1H)-pyrimidinone benzoate
There total 11 articles about (+/-)-2,3-dihydro-1--2-thioxo-4(1H)-pyrimidinone benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) r.t., 19 h; 2.) 2 deg C, 12 days
2: 26.2 g / thionyl chloride, pyridine, DMF / benzene / 2 h / Heating
3: 16.01 g / NH3 / benzene / 0.5 h
4: 85.7 percent / lithium borohydride / tetrahydrofuran / 2 h / Heating
5: 74 percent / Ba(OH)2*8H2O, bromine / H2O / 1.) r.t., 2 h; 2.) 50-65 deg C, 1.25 h
6: 70 percent / methanol; diethyl ether / Ambient temperature
7: 81 percent / 15N aq. ammonia / 0.42 h / 100 °C
8: 0.192 g / pyridine / 48 h / 55 °C
With
pyridine; barium dihydroxide; ammonium hydroxide; lithium borohydride; thionyl chloride; ammonia; bromine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; diethyl ether; water; benzene;
DOI:10.1139/v88-009
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 79 percent / acetic anhydride / 0.5 h / Heating
2: 1.) r.t., 19 h; 2.) 2 deg C, 12 days
3: 26.2 g / thionyl chloride, pyridine, DMF / benzene / 2 h / Heating
4: 16.01 g / NH3 / benzene / 0.5 h
5: 85.7 percent / lithium borohydride / tetrahydrofuran / 2 h / Heating
6: 74 percent / Ba(OH)2*8H2O, bromine / H2O / 1.) r.t., 2 h; 2.) 50-65 deg C, 1.25 h
7: 70 percent / methanol; diethyl ether / Ambient temperature
8: 81 percent / 15N aq. ammonia / 0.42 h / 100 °C
9: 0.192 g / pyridine / 48 h / 55 °C
With
pyridine; barium dihydroxide; ammonium hydroxide; lithium borohydride; thionyl chloride; ammonia; bromine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; diethyl ether; water; acetic anhydride; benzene;
DOI:10.1139/v88-009
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 16.01 g / NH3 / benzene / 0.5 h
2: 85.7 percent / lithium borohydride / tetrahydrofuran / 2 h / Heating
3: 74 percent / Ba(OH)2*8H2O, bromine / H2O / 1.) r.t., 2 h; 2.) 50-65 deg C, 1.25 h
4: 70 percent / methanol; diethyl ether / Ambient temperature
5: 81 percent / 15N aq. ammonia / 0.42 h / 100 °C
6: 0.192 g / pyridine / 48 h / 55 °C
With
pyridine; barium dihydroxide; ammonium hydroxide; lithium borohydride; ammonia; bromine;
In
tetrahydrofuran; methanol; diethyl ether; water; benzene;
DOI:10.1139/v88-009
