(2-phenyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indol-4-yl)methyl formate

Base Information

• Chemical Name: (2-phenyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indol-4-yl)methyl formate
• CAS No.: 1357458-07-1
• Molecular Formula: C₁₉H₁₆N₂O₃
• Molecular Weight: 320.348
• Mol file: 1357458-07-1.mol

Synonyms:

Chemical Property of (2-phenyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indol-4-yl)methyl formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-phenyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indol-4-yl)methyl formate

There total 4 articles about (2-phenyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indol-4-yl)methyl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + N-allyl-N-phenyl-1H-indole-2-carboxamide (545339-34-2) → (2-phenyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indol-4-yl)methyl formate (1357458-07-1)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); copper dichloride; at 150 ℃; for 3h;

DOI:10.1002/adsc.201100614

Reference yield: 69.0%

N-allyl-N-phenyl-1H-indole-3-carboxamide (1357458-18-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (2-phenyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indol-4-yl)methyl formate (1357458-07-1)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); copper dichloride; at 150 ℃; for 3h;

DOI:10.1002/adsc.201100614

Reference yield:

Indole-2-carboxylic acid (1477-50-5,1228050-17-6) → (2-phenyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indol-4-yl)methyl formate (1357458-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 48 h / 0 - 20 °C

2: dichloro bis(acetonitrile) palladium(II); copper dichloride / 3 h / 150 °C

With dmap; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-carbodiimide; copper dichloride; In dichloromethane;

DOI:10.1002/adsc.201100614

upstream raw materials:

N-allyl-N-phenylamine

Indole-2-carboxylic acid

N-allyl-N-phenyl-1H-indole-3-carboxamide

N,N-dimethyl-formamide