trans-1-(2-phenylethyl)-3-methylisonipecotic acid

Base Information

Chemical Name:trans-1-(2-phenylethyl)-3-methylisonipecotic acid
CAS No.:129164-44-9
Molecular Formula:C₁₅H₂₁NO₂
Molecular Weight:247.337
Hs Code.:

Synonyms:

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Chemical Property of trans-1-(2-phenylethyl)-3-methylisonipecotic acid

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Technology Process of trans-1-(2-phenylethyl)-3-methylisonipecotic acid

There total 3 articles about trans-1-(2-phenylethyl)-3-methylisonipecotic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 129164-40-5,129164-41-6
trans-1-(2-phenylethyl)-3-methyl-4-cyanopiperidine

: 129164-44-9,129164-45-0
trans-1-(2-phenylethyl)-3-methylisonipecotic acid

Guidance literature:: With sulfuric acid; water; for 6h; Heating;
DOI:10.1002/jhet.5570270251

Reference yield:

: 82003-82-5
3-methyl-1-phenethylpiperidin-4-one

: 129164-44-9,129164-45-0
trans-1-(2-phenylethyl)-3-methylisonipecotic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3.05 g / potassium t-butoxide / 1,2-dimethoxy-ethane; 2-methyl-propan-2-ol / 2.5 h / Ambient temperature

2: water, conc. sulfuric acid / Heating

With sulfuric acid; potassium tert-butylate; water; In 1,2-dimethoxyethane; tert-butyl alcohol;
DOI:10.1002/jhet.5570270251

Reference yield:

: 82003-82-5
3-methyl-1-phenethylpiperidin-4-one

: 129164-44-9,129164-45-0
cis-1-(2-phenylethyl)-3-methylisonipecotic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3.05 g / potassium t-butoxide / 1,2-dimethoxy-ethane; 2-methyl-propan-2-ol / 2.5 h / Ambient temperature

2: water, conc. sulfuric acid / Heating

With sulfuric acid; potassium tert-butylate; water; In 1,2-dimethoxyethane; tert-butyl alcohol;
DOI:10.1002/jhet.5570270251