bromo-acetic acid 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxymethyl]-2,2-dimethyl-propyl ester

Base Information

• Chemical Name: bromo-acetic acid 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxymethyl]-2,2-dimethyl-propyl ester
• CAS No.: 512198-03-7
• Molecular Formula: C₄₂H₇₁BrO₆Si₂
• Molecular Weight: 808.097
• Mol file: 512198-03-7.mol

Synonyms:

Chemical Property of bromo-acetic acid 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxymethyl]-2,2-dimethyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bromo-acetic acid 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxymethyl]-2,2-dimethyl-propyl ester

There total 7 articles about bromo-acetic acid 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxymethyl]-2,2-dimethyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-bis[4-hydroxy-3-methylphenyl]pentane (55041-27-5) → bromo-acetic acid 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxymethyl]-2,2-dimethyl-propyl ester (512198-03-7)

Guidance literature:

Multi-step reaction with 5 steps

1: NaH / dimethylformamide / 25 °C

2: NaH / dimethylformamide / 80 °C

3: imidazole / CH₂Cl₂ / 25 °C

4: 100 percent / NaBH₄ / methanol / 0.25 h / 0 °C

5: DCC; DMAP / CH₂Cl₂

With 1H-imidazole; dmap; sodium tetrahydroborate; sodium hydride; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00878-8

Reference yield:

ortho-cresol (95-48-7,77504-84-8) → bromo-acetic acid 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxymethyl]-2,2-dimethyl-propyl ester (512198-03-7)

Guidance literature:

Multi-step reaction with 6 steps

1: NaH / dimethylformamide / 25 °C

2: NaH / dimethylformamide / 80 °C

3: imidazole / CH₂Cl₂ / 25 °C

4: 100 percent / NaBH₄ / methanol / 0.25 h / 0 °C

5: DCC; DMAP / CH₂Cl₂

With 1H-imidazole; dmap; sodium tetrahydroborate; sodium hydride; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00878-8

Reference yield:

pentan-3-one (96-22-0) → bromo-acetic acid 1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxymethyl]-2,2-dimethyl-propyl ester (512198-03-7)

Guidance literature:

Multi-step reaction with 6 steps

1: NaH / dimethylformamide / 25 °C

2: NaH / dimethylformamide / 80 °C

3: imidazole / CH₂Cl₂ / 25 °C

4: 100 percent / NaBH₄ / methanol / 0.25 h / 0 °C

5: DCC; DMAP / CH₂Cl₂

With 1H-imidazole; dmap; sodium tetrahydroborate; sodium hydride; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00878-8

upstream raw materials:

bromoacetic acid

1-[4-(1-{4-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenoxy]-3,3-dimethyl-butan-2-ol

3,3-bis[4-hydroxy-3-methylphenyl]pentane

ortho-cresol