Technology Process of (3S,4R)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-carbomethoxyazetidin-2-one
There total 8 articles about (3S,4R)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-carbomethoxyazetidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pTSA / 18 h / Heating
2.1: 90 percent / PPh3; diisopropyl azodicarboxylate / CH2Cl2 / 48 h / 20 °C
3.1: KOH / methanol; H2O / 24 h / 20 °C
4.1: 97.5 percent / PPh3 / CH2Cl2 / 15 h / 20 °C
5.1: titanium tetrachloride; TEA / CH2Cl2 / 0.33 h / -78 °C
5.2: CH2Cl2 / 18 h / -78 - 20 °C
5.3: 0.065 g / TFA / H2O / 0.92 h / 0 - 20 °C
6.1: sodium metaperiodate / ethyl acetate; H2O / 1.5 h / 0 °C
7.1: potassium permanganate / acetone; H2O / 0.83 h
8.1: 0.082 g / diethyl ether / 1.5 h
With
potassium hydroxide; potassium permanganate; sodium periodate; di-isopropyl azodicarboxylate; TEA; titanium tetrachloride; toluene-4-sulfonic acid; triphenylphosphine;
In
methanol; diethyl ether; dichloromethane; water; ethyl acetate; acetone;
2.1: Mitsunobu reaction;
DOI:10.1021/jo020617u
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 90 percent / PPh3; diisopropyl azodicarboxylate / CH2Cl2 / 48 h / 20 °C
2.1: KOH / methanol; H2O / 24 h / 20 °C
3.1: 97.5 percent / PPh3 / CH2Cl2 / 15 h / 20 °C
4.1: titanium tetrachloride; TEA / CH2Cl2 / 0.33 h / -78 °C
4.2: CH2Cl2 / 18 h / -78 - 20 °C
4.3: 0.065 g / TFA / H2O / 0.92 h / 0 - 20 °C
5.1: sodium metaperiodate / ethyl acetate; H2O / 1.5 h / 0 °C
6.1: potassium permanganate / acetone; H2O / 0.83 h
7.1: 0.082 g / diethyl ether / 1.5 h
With
potassium hydroxide; potassium permanganate; sodium periodate; di-isopropyl azodicarboxylate; TEA; titanium tetrachloride; triphenylphosphine;
In
methanol; diethyl ether; dichloromethane; water; ethyl acetate; acetone;
1.1: Mitsunobu reaction;
DOI:10.1021/jo020617u
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 97.5 percent / PPh3 / CH2Cl2 / 15 h / 20 °C
2.1: titanium tetrachloride; TEA / CH2Cl2 / 0.33 h / -78 °C
2.2: CH2Cl2 / 18 h / -78 - 20 °C
2.3: 0.065 g / TFA / H2O / 0.92 h / 0 - 20 °C
3.1: sodium metaperiodate / ethyl acetate; H2O / 1.5 h / 0 °C
4.1: potassium permanganate / acetone; H2O / 0.83 h
5.1: 0.082 g / diethyl ether / 1.5 h
With
potassium permanganate; sodium periodate; TEA; titanium tetrachloride; triphenylphosphine;
In
diethyl ether; dichloromethane; water; ethyl acetate; acetone;
DOI:10.1021/jo020617u
