5-methoxy-3-benzylbenzindole-1-acetonitrile

Base Information

Chemical Name:5-methoxy-3-benzylbenzindole-1-acetonitrile
CAS No.:132205-86-8
Molecular Formula:C₂₂H₁₈N₂O
Molecular Weight:326.398
Hs Code.:

5-methoxy-3-benzylbenz<e>indole-1-acetonitrile

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Chemical Property of 5-methoxy-3-benzylbenzindole-1-acetonitrile

Chemical Property:

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Technology Process of 5-methoxy-3-benzylbenzindole-1-acetonitrile

There total 3 articles about 5-methoxy-3-benzylbenzindole-1-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.3%

: 143-33-9,25596-52-5
sodium cyanide

: (3-Benzyl-5-methoxy-3H-benzo[e]indol-1-ylmethyl)-trimethyl-ammonium; iodide

: 132205-87-9
1-methyl-2-cyano-5-methoxy-3-benzylbenzindole

: 132205-86-8
5-methoxy-3-benzylbenzindole-1-acetonitrile

Guidance literature:: In N,N-dimethyl-formamide; for 4h; Heating;
DOI:10.1021/jo00006a052

Reference yield:

: 132205-82-4
5-methoxy-3-benzyl-3H-benzindole

: 132205-86-8
5-methoxy-3-benzylbenzindole-1-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 35.6 percent / glacial acetic acid / 1.) 0 deg C -> room temperature, 2.) 4 h

2: 89.7 percent / benzene

3: 35.3 percent / dimethylformamide / 4 h / Heating

With acetic acid; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00006a052

Reference yield:

: 132205-84-6
(3-Benzyl-5-methoxy-3H-benzo[e]indol-1-ylmethyl)-dimethyl-amine

: 132205-86-8
5-methoxy-3-benzylbenzindole-1-acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 89.7 percent / benzene

2: 35.3 percent / dimethylformamide / 4 h / Heating

In N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00006a052