Technology Process of (5Z,8Z,10E,12E,14R,15S)-14,15-dihydroxyicosa-5,8,10,12-tetraenoic acid
There total 24 articles about (5Z,8Z,10E,12E,14R,15S)-14,15-dihydroxyicosa-5,8,10,12-tetraenoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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82263-61-4,77667-09-5
(5Z,8Z,10E,12E,14R,15S)-14,15-dihydroxyicosa-5,8,10,12-tetraenoic acid
- Guidance literature:
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With
lithium hydroxide monohydrate;
In
methanol; water;
at 20 ℃;
for 1h;
DOI:10.1039/c8ob02116c
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82263-61-4,77667-09-5
(5Z,8Z,10E,12E,14R,15S)-14,15-dihydroxyicosa-5,8,10,12-tetraenoic acid
- Guidance literature:
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Multi-step reaction with 11 steps
1.1: pyridinium chlorochromate; silica gel / dichloromethane / 8 h / 20 °C
2.1: Noyori's catalyst / dichloromethane; isopropyl alcohol / 11 h / 20 °C
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / diethyl ether; toluene / 4 h / 20 °C
4.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
5.1: oxygen; ozone / ethyl acetate / 0.25 h / -78 °C
5.2: 0.5 h / -78 - 20 °C
6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
6.2: 1 h / 0 - 20 °C
7.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.5 h / -78 °C
8.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.25 h / -78 °C
8.2: 0.25 h / -78 - 0 °C
9.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C
9.2: 1 h / -78 - 20 °C
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
11.1: lithium hydroxide monohydrate / methanol; water / 1 h / 20 °C
With
1H-imidazole; Noyori's catalyst; oxalyl dichloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; oxygen; sodium hexamethyldisilazane; silica gel; sodium hydride; diisobutylaluminium hydride; ozone; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1039/c8ob02116c
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82263-61-4,77667-09-5
(5Z,8Z,10E,12E,14R,15S)-14,15-dihydroxyicosa-5,8,10,12-tetraenoic acid
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / diethyl ether; toluene / 4 h / 20 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
3.1: oxygen; ozone / ethyl acetate / 0.25 h / -78 °C
3.2: 0.5 h / -78 - 20 °C
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
4.2: 1 h / 0 - 20 °C
5.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.5 h / -78 °C
6.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.25 h / -78 °C
6.2: 0.25 h / -78 - 0 °C
7.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C
7.2: 1 h / -78 - 20 °C
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
9.1: lithium hydroxide monohydrate / methanol; water / 1 h / 20 °C
With
1H-imidazole; oxalyl dichloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; oxygen; sodium hexamethyldisilazane; sodium hydride; diisobutylaluminium hydride; ozone; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c8ob02116c
