{(S)-1-[(S)-2-(5-{4-[6-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}phenyl)thieno[3,2-b]thiophen-3-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamicacid methyl ester

Base Information

• Chemical Name: {(S)-1-[(S)-2-(5-{4-[6-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}phenyl)thieno[3,2-b]thiophen-3-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamicacid methyl ester
• CAS No.: 1312546-37-4
• Molecular Formula: C₄₆H₅₂N₈O₆S₂
• Molecular Weight: 877.101

Synonyms:

Chemical Property of {(S)-1-[(S)-2-(5-{4-[6-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}phenyl)thieno[3,2-b]thiophen-3-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamicacid methyl ester

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Technology Process of {(S)-1-[(S)-2-(5-{4-[6-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}phenyl)thieno[3,2-b]thiophen-3-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamicacid methyl ester

There total 5 articles about {(S)-1-[(S)-2-(5-{4-[6-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}phenyl)thieno[3,2-b]thiophen-3-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamicacid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

(S,S)-[2-methyl-1-(2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-imidazol-2-yl}-pyrrolidine-1-carbonyl)-propyl]-carbamic acid methyl ester + 3,6-dibromothieno[3,2,b]thiophene + [(S)-1-((S)-2-{4-[4-(6-bromothieno[3,2-b]thiophen-3-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamic acid methyl ester (1312547-05-9) → {(S)-1-[(S)-2-(5-{4-[6-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}phenyl)thieno[3,2-b]thiophen-3-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamicacid methyl ester (1312546-37-4)

Guidance literature:

Reference yield: 28.0%

(S,S)-[2-methyl-1-(2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-imidazol-2-yl}-pyrrolidine-1-carbonyl)-propyl]-carbamic acid methyl ester + [(S)-1-((S)-2-{4-[4-(6-bromothieno[3,2-b]thiophen-3-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamic acid methyl ester (1312547-05-9) + 3,6-dibromothiophene[3,2-b]thiophene (392662-65-6) → {(S)-1-[(S)-2-(5-{4-[6-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}phenyl)thieno[3,2-b]thiophen-3-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamicacid methyl ester (1312546-37-4)

Guidance literature:

Reference yield: 28.0%

→ {(S)-1-[(S)-2-(5-{4-[6-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}phenyl)thieno[3,2-b]thiophen-3-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamicacid methyl ester (1312546-37-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 1h;

upstream raw materials:

[(S)-1-((S)-2-{4-[4-(6-bromothieno[3,2-b]thiophen-3-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamic acid methyl ester

3,6-dibromothiophene[3,2-b]thiophene

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