3-bromo-2-phenylsulfinyl-1-phenylsulfonylindole

Base Information

• Chemical Name: 3-bromo-2-phenylsulfinyl-1-phenylsulfonylindole
• CAS No.: 145887-97-4
• Molecular Formula: C₂₀H₁₄BrNO₃S₂
• Molecular Weight: 460.372
• Mol file: 145887-97-4.mol

Synonyms:

Chemical Property of 3-bromo-2-phenylsulfinyl-1-phenylsulfonylindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-bromo-2-phenylsulfinyl-1-phenylsulfonylindole

There total 1 articles about 3-bromo-2-phenylsulfinyl-1-phenylsulfonylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

3-bromo-1-phenylsulfonyl-2-phenylthioindole (145887-95-2) → 3-bromo-2-phenylsulfinyl-1-phenylsulfonylindole (145887-97-4) + 3-bromo-1,2-diphenylsulfonylindole (145887-99-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 14h; Ambient temperature;

Reference yield:

3-bromo-2-phenylsulfinyl-1-phenylsulfonylindole (145887-97-4) → 3-bromo-2-deutero-1-phenylsulfonylindole (145887-94-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) PhMgBr, anthracene, 2.) MeI / 1.) diglyme, Et₂O, reflux, 10 h, 2.) diglyme, Et₂O, overnight

2: 1.) LDA, 2.) CNBr / 1.) THF, heptane, -78 deg C, 40 min, 2.) THF, heptane, RT, overnight

3: 1.) tert-BuLi, 2.) 2,5-dimethylfuran, 3.) D₂O

With 2,5-dimethylfuran; bromocyane; anthracene; water-d2; tert.-butyl lithium; phenylmagnesium bromide; lithium diisopropyl amide; methyl iodide;

Reference yield:

3-bromo-2-phenylsulfinyl-1-phenylsulfonylindole (145887-97-4) → 3-bromo-1-phenylsulfonyl indole (99655-68-2)

Guidance literature:

With anthracene; phenylmagnesium bromide; methyl iodide; Yield given. Multistep reaction; 1.) diglyme, Et₂O, reflux, 10 h, 2.) diglyme, Et₂O, overnight;

upstream raw materials:

3-bromo-1-phenylsulfonyl-2-phenylthioindole

Downstream raw materials:

3-bromo-1-phenylsulfonyl indole

2,3-Dibromo-1-(phenylsulfonyl)indole

3-bromo-2-deutero-1-phenylsulfonylindole

3-bromo-1-phenylsulfonyl-2-phenylthioindole

Refernces