(+/-)-trans-2-amino-cyclopentane carboxylic acid

Base Information

• Chemical Name: (+/-)-trans-2-amino-cyclopentane carboxylic acid
• CAS No.: 57043-01-3
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.159
• Mol file: 57043-01-3.mol

Synonyms:

Chemical Property of (+/-)-trans-2-amino-cyclopentane carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-trans-2-amino-cyclopentane carboxylic acid

There total 8 articles about (+/-)-trans-2-amino-cyclopentane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

((1S,2S)-2-Cyano-cyclopentyl)-carbamic acid tert-butyl ester → (+/-)-trans-2-amino-cyclopentane carboxylic acid (57043-01-3,37910-65-9)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1016/S0040-4039(02)01085-7

Reference yield: 84.0%

benzyl trans-2-(benzylamino)cyclopentane-1-carboxylate → (+/-)-trans-2-amino-cyclopentane carboxylic acid (57043-01-3,37910-65-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;

DOI:10.1081/SCC-100105666

Reference yield: 78.0%

cis-2-aza-3-oxobicyclo<3.2.0>heptane (22031-52-3,39155-94-7,39155-95-8,83151-31-9) → (1RS,2SR)-cispentacin (57043-00-2,37910-65-9) + (+/-)-trans-2-amino-cyclopentane carboxylic acid (57043-01-3,37910-65-9)

Guidance literature:

cis-2-aza-3-oxobicyclo<3.2.0>heptane; With sodium ethanolate; In ethanol; for 12h; Heating;

With hydrogenchloride; for 24h; Heating;

DOI:10.1007/s007060200077

upstream raw materials:

cyclopent-1-enecarboxylic acid

(±)-trans-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid

cis-2-aza-3-oxobicyclo<3.2.0>heptane

Downstream raw materials:

trans-2-carbobenzyloxyamino-1-cyclopentanecarboxylic acid

ethyl trans-2-amino-1-cyclopentanecarboxylate hydrochloride

trans-2-aminocyclopentanecarboxamide

{2-[((1S,2S)-2-Benzyloxycarbonylamino-cyclopentanecarbonyl)-amino]-acetylamino}-acetic acid ethyl ester